1-(2-Hydroxyethyl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxylic acid

1-(2-Hydroxyethyl)-4-methyl -5-(2-(trifluoromethyl) phenyl)-1H-pyrrole-3-carboxylic acid (CAS 1631030-72-2), molecular formula Cdecision NO, molecular weight 313.27, conventional purity ≥ 98%. The trifluoromethyl substituted pyrrole carboxylic acid skeleton is an important pharmaceutical intermediate and organic synthetic building block, which is widely used in the field of new drug research and development, fine chemical industry and customized synthesis.

nature

this product is containing trifluoromethyl and hydroxyethyl substituted pyrrole carboxylic acid derivatives, room temperature is solid powder. The density is about 1.34g/cm³, the predicted boiling point is 456.1±45.0°C, and the acidity coefficient pKa is about 5.43±0.50, showing the weak acidity characteristics of typical carboxylic acids. The trifluoromethyl group in the molecule gives it some lipid solubility and metabolic stability, while the hydroxyethyl group provides a hydroxyl site for further derivatization. It is recommended to store in a sealed and dry environment at 2-8°C to avoid moisture absorption and long-term exposure to strong oxidizing conditions.

Use

the core value of this compound lies in the trifluoromethyl substituted pyrrole carboxylic acid skeleton, which is a multifunctional building block commonly used in drug discovery and fine chemicals. The carboxylic acid site can be subjected to conventional transformations such as amidation and esterification, and the substituents on the hydroxyethyl group and the pyrrole ring provide multiple accessible sites for further structural modification. In pharmaceutical research and development, such intermediates are often used to construct candidate active molecules with metabolic stability and specific electronic effects, which are suitable for the development of new drug process routes and customized synthesis projects.

Safety Information

as a fine chemical, the operation should still follow the standard laboratory safety regulations: wear protective gloves and goggles to avoid dust inhalation and direct contact with eyes and skin; use in a well-ventilated environment, and keep the storage area closed, dry and away from oxidizing substances.

Why Choose Us: Production Advantages and Capacity

① Source factory direct supply, non-trade change of hands. Direct supply from our own production base, batch-to-batch consistency and traceability of the whole process are fundamentally guaranteed, reducing quality fluctuations and delivery uncertainty caused by intermediate links.

The purity is controllable and the data is complete. Routine purity ≥ 98%(HPLC), COA for each batch to support customer audit and quality traceability requirements; higher specifications can be customized according to project needs.

③ Flexible supply capacity from gram to ton. The standing inventory of g-class to kg-class, stable delivery of 100kg-class, and ton-class process and capacity reserves can match the full-cycle demand from early research and development to large-scale production, avoiding the risk of “small-scale purchase, large-scale supply.

④ The technology platform is mature and the customized response is fast. The company has accumulated mature platform experience in deuteration technology, heterocyclic synthesis and process optimization, and has the ability to systematically solve the derivatization, process amplification and impurity control of trifluoromethylpyrrole carboxylic acid structures, and can cooperate with customers to complete the connection from route screening to commercial production.

⑤ Focus on “difficult, easy to break, high demand” intermediates. We do not do the simple handling of homogeneous bulk varieties, but build process barriers and supply resilience around high value-added pharmaceutical intermediates-the core reason why customers choose us is to obtain supply chain security with quality determination, delivery date determination and amplification path determination on key projects.

FAQ

q1: How much packing can you provide? What is the minimum order quantity? A: We support the supply of samples from gram/milligram to ton. There is no hard minimum order threshold. Specific packaging specifications (bottled, aluminum, cardboard, etc.) can be negotiated according to your consumption and transportation requirements.

Q2: What is this product used for? Is it an intermediate of esalidone? A: Yes. This compound is a key chiral aryl pyrrole intermediate of Esaxerenone, which is used to construct the molecular skeleton of non-steroidal mineralocorticoid receptor antagonists.

Q3: What is the conventional purity and is it possible to provide customized purity or specific impurity control? A: The purity of conventional supply can be above 98% according to demand, and specifications such as specific impurity limit, chiral purity and particle size can be negotiated according to downstream API process requirements. Please provide your specifications and we will feedback the feasible quality control scheme.

Q4: What are the storage conditions? Do you need a cold chain? A: Public COA reference information recommends storage at -20°C, dry, dark, and the compound is hygroscopic. We will provide appropriate packaging and insulation measures when shipping according to the transportation time and destination. The specific conditions can be locked at the time of order confirmation.

Q5: Are you a trader or a producer? Can you provide regulatory documentation support? A: Shanghai Lizhuo Pharmaceutical is a production-oriented supplier. This product is a conventional production product. We can provide COA with the goods, and according to customer needs to assist in providing MSDS and the necessary regulatory support documents.

Welcome to visit our official website for detailed product specifications and cooperation methods: https://www.shlzpharma.com/