2-Iodoxybenzoic Acid (Cas No.61717-82-6): A Versatile Hypervalent Iodine Reagent with Premium Industrial Supply

2-Iodoxybenzoic Acid, abbreviated as IBX (Cas No.61717-82-6), stands as a pivotal hypervalent iodine(III) compound and an indispensable organic oxidizing reagent in modern synthetic chemistry. Distinguished by its mild oxidation properties, high reaction selectivity, and broad substrate compatibility, IBX has revolutionized the synthesis of fine chemicals, pharmaceutical intermediates, and natural products, replacing many traditional toxic and heavy-metal-based oxidants in industrial and laboratory applications. Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. , a leading manufacturer of pharmaceutical intermediates and high-purity fine chemical reagents, has achieved the large-scale, high-purity and stable production of 2-Iodoxybenzoic Acid through independent R&D of synthetic processes and strict quality control. Leveraging our strong R&D strength, advanced production facilities and global service network, we provide tailor-made supply solutions and high-quality products for chemical research institutions, pharmaceutical enterprises and fine chemical manufacturers worldwide, solidifying our position as a reliable partner in the global synthetic chemistry industry.

I. Core Identification and Physicochemical Properties of 2-Iodoxybenzoic Acid

1. Basic Product Identification Information

English Name: 2-Iodoxybenzoic Acid; o-Iodoxybenzoic acid; IBXCas Registration Number: 61717-82-6Molecular Formula: C₇H₅IO₄Molecular Weight: 280.02 g/molStructural Formula: C₆H₄(IO₂)COOHEINECS Number: 263-113-5

As a classic hypervalent iodine compound, IBX features a three-center four-electron (3c-4e) I-O bond in its molecular structure, which is the fundamental reason for its unique oxidizing activity and structural stability. Different from other iodine-based oxidants, its benzoic acid moiety enhances its solubility in specific organic solvents and reaction selectivity, making it a favored oxidant in selective oxidation reactions.

2. Key Physicochemical Properties

2-Iodoxybenzoic Acid is a white to pale yellow crystalline solid under room temperature and normal pressure, with unique physicochemical characteristics that adapt to a variety of organic synthesis conditions; its core properties are as follows:

• Solubility: A distinctive feature of IBX is its poor solubility in common non-polar organic solvents (e.g., hexane, benzene, ether) and cold water, but it is soluble in polar aprotic solvents (e.g., DMSO, DMF) and hot water (≥80℃). It can also form soluble adducts with carboxylic acids or amines, expanding its application in different reaction systems;
• Melting & Decomposition Point: Decomposes at approximately 230℃ (no obvious melting point before thermal decomposition), with good thermal stability at room temperature and under inert gas protection (stable for more than 12 months when stored properly). It is suitable for organic synthesis reactions at 0-180℃;
• Oxidation Properties: Mild and selective oxidizing agent, mainly used for the oxidation of primary alcohols to aldehydes, secondary alcohols to ketones, and the oxidation of 1,2-diols to diketones, without over-oxidation of products (e.g., no oxidation of aldehydes to carboxylic acids). It also exhibits high reactivity in the oxidation of sulfides to sulfoxides and the dehydrogenation of heterocyclic compounds;
• Stability & Hygroscopy: Non-hygroscopic, stable in dry air and at room temperature, and does not react with non-oxidizable organic compounds under normal conditions. It is sensitive to strong reducing agents (e.g., sulfites, hydrazine) and strong acids, and will undergo reduction or hydrolysis reactions;
• Storage & Transportation Requirements: Stored in a sealed, dry, cool and dark environment (0-25℃), isolated from reducing agents, strong acids, combustibles and direct sunlight. Packed in airtight HDPE drums or aluminum foil vacuum bags; transported as a non-hazardous chemical (no corrosivity, flammability or toxicity), with simple and safe transportation conditions compared with traditional oxidants.

3. Industrial and Research Grade Quality Standards

Shanghai Lizhuo Pharmaceutical has formulated differentiated quality standards for 2-Iodoxybenzoic Acid (Cas No.61717-82-6) based on international synthetic chemistry reagent specifications and customer application scenarios (research and industrial production), with product quality meeting the high requirements of pharmaceutical, fine chemical and academic research fields:

• Purity: Research grade ≥99.0%, industrial grade ≥98.5%, single impurity content ≤0.3% (no detectable heavy metal impurities);
• Moisture Content: ≤0.2% (Karl Fischer titration), avoiding the impact of trace water on oxidation reaction selectivity;
• Oxidation Activity: The effective iodine content is ≥38.5% (theoretical value 38.9%), ensuring consistent and high reaction conversion rate (≥98% in standard alcohol oxidation reactions);
• Insoluble Residue: ≤0.05% in DMSO, no insoluble impurities that block reaction equipment or affect product separation;
• Stability: The product’s oxidation activity retention rate is ≥99% after 6 months of storage under standard conditions, meeting the long-term use requirements of industrial production and laboratory research.

II. Application Fields and Global Market Development of 2-Iodoxybenzoic Acid (Cas No.61717-82-6)

As a green and efficient hypervalent iodine oxidant, 2-Iodoxybenzoic Acid has gradually replaced traditional heavy metal oxidants (e.g., chromium trioxide, manganese dioxide) and toxic organic oxidants due to its mild reaction conditions, high selectivity and environmental friendliness, and its application covers pharmaceutical R&D and production, fine chemical synthesis, natural product extraction and modification, and organic chemistry research. With the global chemical industry’s shift towards green and sustainable development and the continuous expansion of the pharmaceutical and fine chemical markets, the demand for high-purity IBX is showing a rapid growth trend, and its market application value is constantly expanding.

1. Core Application Fields

(1) Pharmaceutical R&D and Production: Key Oxidant for API Synthesis

IBX is an essential oxidizing reagent in the synthesis of active pharmaceutical ingredients (APIs) and pharmaceutical intermediates, widely used in the synthesis of anti-tumor drugs, cardiovascular drugs, anti-inflammatory drugs and antiviral drugs. For example, in the synthesis of anti-tumor natural products (e.g., taxol derivatives and camptothecin), it is used for the selective oxidation of alcohol groups to carbonyl groups, a key step in constructing the active molecular skeleton of drugs; in the synthesis of beta-blockers (a class of cardiovascular drugs), it realizes the high-selectivity oxidation of secondary alcohols to ketones, avoiding the generation of by-products and simplifying the post-reaction separation process. In addition, IBX is also used in the synthesis of chiral pharmaceutical intermediates, as its mild oxidation properties do not destroy the chiral center of molecules, meeting the strict requirements of chiral drug synthesis for reaction selectivity.

(2) Fine Chemical Synthesis: Green Oxidant for Specialty Chemicals

In the fine chemical industry, IBX is used for the synthesis of high-value specialty chemicals such as fragrances, dyes, and functional materials. In fragrance synthesis, it oxidizes alcohol-based raw materials to aldehyde and ketone fragrances (e.g., vanillin and jasmine aldehyde) with high yield and no off-flavor by-products, improving the purity and quality of fragrances; in dye synthesis, it is used for the oxidation of aromatic amines and phenols to form quinone structures, the core chromophore of many synthetic dyes. Compared with traditional oxidants, IBX’s green characteristics reduce the environmental pollution of fine chemical production and the cost of three waste treatment, complying with the green production requirements of the fine chemical industry.

(3) Natural Product Modification and Extraction

Natural products (e.g., plant extracts, microbial metabolites) are important raw materials for drug R&D and fine chemical production, and IBX plays a key role in their structural modification and purification. It is used for the selective oxidation of hydroxyl groups in natural products to modify their biological activity (e.g., enhancing the anti-inflammatory activity of flavonoid extracts) and for the oxidation of impure alcohols in natural product extracts to volatile carbonyl compounds, which are easily removed by distillation, thus improving the purity of natural product active ingredients. Its mild reaction conditions ensure that the active structure of natural products is not destroyed, making it an ideal oxidant for natural product modification.

(4) Organic Chemistry Research: Classic Reagent for Academic and Industrial R&D

In the field of organic chemistry research, IBX is a classic oxidizing reagent in universities, research institutions and enterprise R&D centers, widely used in the development of new synthetic routes, the study of reaction mechanisms and the synthesis of novel organic compounds. Its unique oxidation properties make it a powerful tool for exploring the selective oxidation of complex molecules, and it is often used in the synthesis of rare heterocyclic compounds and functional organic materials. In addition, IBX is also a key reagent for the preparation of other hypervalent iodine compounds (e.g., Dess-Martin periodinane, DMP), forming a series of hypervalent iodine oxidant products and enriching the types of green oxidants in synthetic chemistry.

2. Global Market Development Status and Demand Trends

Driven by the global green chemistry movement and the rapid development of the pharmaceutical and fine chemical industries, the market for 2-Iodoxybenzoic Acid (Cas No.61717-82-6) has maintained a high growth rate in recent years, with the following core market characteristics and development trends:

1. Rapid growth of market demand: The global market compound annual growth rate (CAGR) of IBX has reached 15%-20% in the past five years, driven by the replacement of traditional heavy metal oxidants and the expansion of pharmaceutical R&D pipelines. The market demand is expected to continue to grow at a high rate with the continuous promotion of green production in the chemical industry;
2. Increasing demand for high-purity products: Pharmaceutical and chiral fine chemical production have extremely high requirements for the purity and activity of IBX. The market share of research grade (≥99.0%) and high-purity industrial grade (≥98.5%) IBX is increasing year by year, while low-purity products are gradually phased out;
3. Shift to green and sustainable production: Environmental protection policies in Europe, North America, China and other major chemical markets are becoming increasingly strict, and enterprises are required to use green oxidants to replace toxic and polluting traditional oxidants. IBX, as a non-toxic, heavy-metal-free and recyclable oxidant, has become the first choice for many enterprises, and the market demand for green synthetic process IBX is growing rapidly;
4. Diversification of application scenarios: With the deepening of hypervalent iodine chemistry research, IBX’s application is expanding from traditional alcohol oxidation to the synthesis of functional materials, chiral compounds and electronic chemicals, opening up new market demand space;
5. Concentration of production and demand: The global demand for IBX is mainly concentrated in North America, Europe, China and Japan, where pharmaceutical and fine chemical industries are developed. China has become the world’s major production base of IBX due to its complete chemical industry chain and advanced synthetic technology, and the export volume of high-purity IBX is increasing year by year.

III. Production Advantages and Industrial Capacity of 2-Iodoxybenzoic Acid by Shanghai Lizhuo Pharmaceutical

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. has been deeply engaged in the R&D and production of fine chemical reagents and pharmaceutical intermediates for many years, with a professional R&D team of organic synthetic chemists and a modern production base equipped with advanced precision synthesis equipment. For the production of 2-Iodoxybenzoic Acid (Cas No.61717-82-6), we have broken through the technical bottlenecks of traditional synthetic processes and formed core competitive advantages in synthetic technology, product quality, production capacity flexibility and technical service, which are different from other suppliers. Our stable and efficient industrial production capacity and high-quality products have been highly recognized by global customers.

1. Technological Advantages: Independent R&D of Low-Cost and High-Yield Green Synthetic Process

The traditional synthesis process of IBX has the problems of low yield, high raw material consumption and large three waste discharge (using concentrated sulfuric acid as a solvent and oxidant). Shanghai Lizhuo Pharmaceutical has independently developed a green, efficient and low-consumption synthetic process with independent intellectual property rights through continuous R&D and process optimization, taking 2-iodobenzoic acid as the raw material and using a green oxidant system and mild reaction conditions to realize the industrial production of IBX. Our synthetic process has the following unique advantages:

• High yield and low raw material consumption: The total reaction yield is as high as 92% or more, far higher than the industry average of 75%-80%, and the raw material utilization rate is increased by more than 20%, effectively reducing the production cost;
• Green and environmental protection: Abandon the use of concentrated sulfuric acid and other strong corrosive solvents, adopt water-soluble green oxidants and recyclable polar aprotic solvents (solvent recycling rate ≥95%), and the three waste discharge is reduced by more than 80% compared with the traditional process. The produced wastewater is treated by neutralization and biodegradation to reach the discharge standard, complying with the national environmental protection standards and the global green chemistry development trend;
• Simple post-treatment and high product purity: The reaction product has good crystallinity and can be purified by simple recrystallization (no need for complex column chromatography separation), which is suitable for industrial large-scale production. The product purity can reach more than 99.0% without additional purification steps;
• Mild reaction conditions and high safety: The synthesis reaction is carried out at normal pressure and low temperature (40-60℃), avoiding the high temperature and high pressure conditions of the traditional process, reducing the production safety risks and the requirements for production equipment;
• Strong process scalability: The synthetic process can realize seamless scale-up from laboratory small test (100g level) to industrial large production (ton level), and the product quality and yield remain stable during the scale-up process, meeting the different production scale needs of customers.

2. Quality Advantages: Targeted Quality Control and Full-Process Traceability System

Aiming at the different application scenarios of 2-Iodoxybenzoic Acid (research and industrial production), Shanghai Lizhuo Pharmaceutical has established a targeted quality control system and a full-process product traceability system, adhering to the quality concept of “precision and consistency”, and strictly controlling every link of product production from raw material procurement to finished product delivery:

• Raw material procurement with strict standards: We select well-known domestic and foreign suppliers of 2-iodobenzoic acid with stable quality, and conduct full-item inspection on all incoming raw materials (purity, moisture, impurity content, etc.). The raw material purity is required to be ≥99.5% to ensure the high quality of the final product;
• Stage-by-stage quality detection in production process: Set 3 key quality detection nodes in the synthesis, crystallization and drying stages, use high-performance liquid chromatography (HPLC), ion chromatography (IC) and Karl Fischer moisture meter to detect the product purity, impurity content and moisture in real time, and adjust the process parameters in time according to the detection results to ensure the product quality meets the standards;
• Differentiated quality inspection for finished products: For research grade and industrial grade IBX, different quality inspection items and standards are formulated. Research grade products add the detection of oxidation activity and chiral impurity content, while industrial grade products focus on the detection of insoluble residue and batch consistency, meeting the personalized quality requirements of different customers;
• Perfect product traceability system: Each batch of IBX has a unique batch number and production record, which can realize the full-process traceability of raw material source, production process parameters, detection data, storage and transportation information. Customers can query the product quality report and production information through the batch number, ensuring the transparency and reliability of product quality.

3. Capacity Advantages: Dual Production Lines for Flexible Supply and Sufficient Inventory Reserve

Shanghai Lizhuo Pharmaceutical has built two specialized production lines for 2-Iodoxybenzoic Acid (Cas No.61717-82-6) (research grade and industrial grade) in its modern fine chemical production base, realizing the separate production of different grade products and avoiding cross-contamination. The production lines are equipped with automatic feeding, reaction and crystallization equipment, realizing the automatic and continuous production of IBX, with strong production capacity guarantee and flexible supply capacity:

• Core industrial production capacity: The annual production capacity of industrial grade 2-Iodoxybenzoic Acid is 200 tons/year, and the annual production capacity of research grade products is 50 tons/year, which can fully meet the large-scale procurement needs of global pharmaceutical enterprises and fine chemical manufacturers, and the batch production capacity can reach 5-10 tons per batch;
• Flexible small-batch customization capacity: We have a dedicated small-batch production line for research grade IBX, which can provide customized production services of 100g-50kg for scientific research institutions, universities and small and medium-sized enterprises with trial production needs. The production cycle is short (3-5 working days) and the delivery speed is fast;
• Sufficient inventory reserve: We have built a professional constant temperature and humidity storage warehouse for IBX, with a regular inventory reserve of 20-30 tons (including research grade and industrial grade), which can realize quick delivery and meet the emergency procurement needs of customers;
• Customized packaging capacity: According to the customer’s usage habits and transportation needs, we can provide a variety of packaging specifications (100g/bottle, 1kg/bag, 25kg/drum, 50kg/drum) and packaging materials (aluminum foil vacuum bag, HDPE drum, glass bottle), and the packaging is moisture-proof, light-proof and airtight, ensuring the product stability during transportation and storage.

4. Service Advantages: Professional Technical Support and Global One-Stop Supply Service

Different from ordinary chemical raw material suppliers, Shanghai Lizhuo Pharmaceutical focuses on providing value-added technical services and one-stop supply solutions for customers while providing high-quality 2-Iodoxybenzoic Acid products, adhering to the service concept of “customer-centric, technical-driven”, and creating a full-process service system from product selection to application guidance:

• Professional technical consultation and application guidance: Our technical service team is composed of senior organic synthetic chemists with rich experience in IBX application, who can provide customers with comprehensive technical support such as product selection, reaction process optimization, post-treatment method improvement and safety use guidance. For industrial customers, we can also send technical personnel to the customer’s production site for on-site debugging and process optimization to ensure the smooth application of IBX in the customer’s production process;
• Customized product development service: According to the customer’s special application requirements (e.g., higher purity, special solubility, modified oxidation activity), our R&D team can carry out customized product development and process optimization, and provide small-batch trial production services to meet the personalized needs of customers;
• Global one-stop supply and logistics service: We have established a global sales and logistics network, and cooperate with well-known international logistics enterprises to realize the global delivery of IBX products (including express delivery for small batches and sea/air transportation for large batches). The product can be delivered to more than 50 countries and regions around the world, with a on-time delivery rate of 100%. For overseas customers, we also provide customs clearance documents and product quality certification (COA, MSDS) that meet international standards;
• Long-term stable cooperation and after-sales service: For long-term cooperative customers, we formulate personalized long-term supply plans, lock in product prices and production capacity, ensure the stable supply of products, and avoid the impact of market price fluctuations and supply shortage on the customer’s production. We provide a 7×24-hour after-sales service hotline, and respond to customer’s product quality and application problems in a timely manner, with a problem solving rate of 100%.

IV. Enterprise Strength and Sustainable Development of Shanghai Lizhuo Pharmaceutical

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. is a subsidiary of Shenzhen Rich Chemical Technology Co., Ltd., with strong capital strength, advanced technical R&D capacity and a complete industrial production system. The company is mainly engaged in the R&D, production and sales of pharmaceutical intermediates, fine chemical reagents, small molecule building blocks and new drug reference substances, and is committed to providing global pharmaceutical companies and new drug R&D institutions with R&D and customized production services covering the entire life cycle of pharmaceutical intermediates from early clinical research to drug listing.

We have an organic chemical synthesis laboratory equipped with advanced precision synthesis and detection equipment (HPLC, GC, NMR, IC, etc.), and a professional R&D team composed of doctors, masters and senior engineers with rich experience in fine chemical synthesis and pharmaceutical intermediate R&D. The company has obtained a number of national invention patents for synthetic processes, and has successively passed ISO9001 quality management system, ISO14001 environmental management system and OHSAS18001 occupational health and safety management system certification, with product quality meeting international standards. In addition, we participate in the CPHI, PMEC and other international pharmaceutical and chemical exhibitions every year, and establish long-term strategic cooperative relationships with many well-known pharmaceutical and fine chemical enterprises around the world, with a good brand reputation in the global market.

For 2-Iodoxybenzoic Acid (Cas No.61717-82-6) and other hypervalent iodine compounds, we will continue to increase R&D investment, further optimize the synthetic process, improve product quality and production capacity, and develop a series of hypervalent iodine oxidant products (e.g., DMP, Togni’s reagent) to form a complete product line of hypervalent iodine reagents and meet the diversified market demand. At the same time, we will always adhere to the development concept of green, low-carbon and sustainable development, continue to upgrade the environmental protection production equipment and technology, reduce the environmental impact of production activities, and realize the coordinated development of enterprise development and environmental protection.

As a professional and reliable manufacturer of 2-Iodoxybenzoic Acid (Cas No.61717-82-6), Shanghai Lizhuo Pharmaceutical is willing to work hand in hand with global customers in the pharmaceutical, fine chemical and organic chemistry research fields, with high-quality products, advanced technology and perfect service, to promote the development of green synthetic chemistry and create greater value for the global chemical and pharmaceutical industry. If you have procurement needs, customized production requirements or technical consultation on 2-Iodoxybenzoic Acid (Cas No.61717-82-6), please contact us through our official website, and our professional team will provide you with high-quality and efficient one-stop solutions!