1. product basic information table
| Name | 4-amino -5-methyl -2-hydroxyl pyridine |
| Alias | 4-Amino-2-hydroxy-5-methylpyridine; 4-Amino-5-methylpyridin-2(1H)-one; 4-Amino-5-methyl-1H-pyridin-2-one; Finerenone Impurity A; Finerenone intermediate; Degarelix Impurity 4 |
| CAS No. | 95306-64-2 |
| EINECS No. | 682-818-3 |
| chemical formula | C₆H₈N₂O |
| molecular weight | 124.14 g/mol |
| InChI | InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9) |
| density | 1.137±0.06 g/cm³(20 °C,760 Torr) |
| boiling Point | 291.0±33.0°C(760 Torr)(other predicted 408.7±40.0°C, calculated) |
| flash Point | 129.8±25.4°C |
| water soluble | insoluble in water; Soluble in strongly polar organic solvents |
| vapor pressure | 0-0 Pa(20-50 °C) |
| storage conditions | 2-8°C, protected from light |
| sensitivity | sensitive to light; avoid contact with strong oxidants, strong acids, acid anhydrides, acid chlorides |
| appearance | white to off-white or light brown solid (powder) |
| specific Gravity | approximately 1.137g/cm³(20°C), consistent with density values |
| color | white to off-white, or light brown |
| MDL No. | MFCD12546373 |
| dangerous Goods Signs | GHS07 (exclamation mark, Exclamation Mark); Signal word: Warning |
| risk Terms | H302 (harmful if swallowed);H315 (causes skin irritation);H319 (causes severe eye irritation);H335 (may cause respiratory irritation) |
| safety terminology | P261 (avoid inhaling dust/smoke/gas/mist/vapour/spray);P305 + P351 + P338 (if entering eyes: rinse carefully with water for a few minutes, if wearing contact lenses and can be easily removed, remove contact lenses and continue rinsing) |
| customs Number | there is no public and accurate customs code corresponding to the CAS number; as a pyridine pharmaceutical intermediate, it can usually be classified under the relevant HS code of pyridine and its derivatives, and the actual declaration shall be subject to the latest customs tariff and product use. |
2. Nature
4-Amino-5-methyl-2-hydroxypyridine is a pyridine derivative containing amino and hydroxyl groups. There are two tautomeric forms of pyridine-2-ol and pyridine-2 (1H)-one (2-pyridone) in the molecule. Under most conditions, the ketone form is dominant, and this tautomeric property directly affects its reaction site and derivatization path. The appearance is a white to off-white or light brown solid with a melting point reported in the literature of about 265-270°C (with decomposition). In terms of solubility, the compound is insoluble in water, but soluble in strongly polar organic solvents. Storage should be protected from light, low temperature (2-8°C) and sealed to prevent degradation.
3. uses
the core use of the compound is as a key synthetic intermediate of non-nelidone in the treatment of diabetic nephropathy. As a non-steroidal selective mineralocorticoid receptor antagonist, 4-amino -5-methyl -2-hydroxypyridine is an important building block for the construction of active molecular skeleton in its industrial synthesis route. In addition, it is also widely used as a general intermediate in organic synthesis and medicinal chemistry, and can be used for the structural modification and preparation of a variety of drug molecules, including the synthesis of antihistamines, antipsychotics, and anticonvulsants. In supplier catalogs, the product is often labeled as a “pharmaceutical grade intermediate”, with packaging specifications ranging from grams to 25kg/barrel, suitable for research and development, pilot and commercial production stages.
4. safety information
the product is classified as a warning level substance according to GHS, the danger sign is GHS07 (exclamation mark), and the signal word is Warning. The main hazards include: Harmful swallowing (H302), skin irritation (H315), severe eye irritation (H319), and possible respiratory irritation (H335). The operation should be carried out in a fume hood to avoid dust generation and inhalation; wear nitrile gloves, lab clothes and chemical safety goggles. In case of skin or eye contact, rinse immediately with plenty of water and seek medical advice. Storage should be with strong oxidants, strong acid, acid anhydride, acid chloride stored separately to prevent incompatible reaction. During the leakage treatment, dust shall be prevented from flying, and inert materials shall be absorbed and collected for disposal as hazardous waste.
5. our production advantages and capacity
shanghai Lizhuo Pharmaceutical Technology Co., Ltd ( https://www.shlzpharma.com/ ) 4-amino -5-methyl -2-hydroxyl pyridine (CAS 95306-64-2) is listed as a conventional production product, with a stable supply capacity from small samples to tons. The conventional purity is 98%, the appearance is white powder, and the storage condition is clearly 2-8°C to avoid light, which can provide customers with batch quality inspection data support. For the demand for intermediates for downstream drugs such as non-nellione, our company can provide continuous supply from kg to ton, taking into account the flexibility of small quantities in the research and development screening stage and the stability of large quantities in the commercial production stage. Welcome to visit the official website https://www.shlzpharma.com/ get product details and cooperation contact information.
Post time: Oct-28-2026
