(4R)-2,2-dimer-[1,3]dioxolan-4-ylmethoxyamine

List of Basic Product Information

nature

the compound is a chiral hydroxylamine derivative containing both a 1,3-dioxolane ketal protecting group and an O-substituted hydroxylamine (aminooxy) functional group in the molecule. The ketal structure is stable under alkaline and neutral conditions, and can be deprotected to release 1,2-diol fragments under mild acidic conditions. The lone pair electron on the oxygen atom of hydroxylamine makes it have strong nucleophilicity, which can efficiently react with aldehyde groups for oxime/oxime linkage, and is widely used as an orthogonal linkage handle in glycochemistry, glycoprotein modification and polysaccharide-drug coupling. The C4 chiral center in the molecule determines the stereochemical trend of the product and has a clear value in asymmetric synthesis and chiral block construction. The flash point is about 93.9°C, which belongs to the category of flammable but non-flammable liquid. GHS classification shows that there are certain hazards in swallowing, skin contact and inhalation, and basic protection and ventilation should be done during operation.

Use

1.

Drug development intermediates: as chiral building blocks containing hydroxylamine fragments, they are used to construct candidate drug molecules of oximes, isoxazoles and hydroxamic acids, which are commonly used in the early stages of anti-tumor, anti-viral and enzyme inhibitor projects.

2.

Orthogonal protecting/linking reagents in carbohydrate chemistry and bioconjugation: ketal-protected hydroxylamines can be deprotected under acidic conditions to release reactive aminooxy groups for selective protection-deprotection sequences in oligosaccharide synthesis, or for fluorescent labeling and functional modification of oxidized polysaccharides (e. g., oxidized hyaluronic acid, oxidized cellulose).

3.

Analytical reference substances and method development: Due to the clear structure and chiral purity, it can be used as a reference substance or system applicability sample in the development of LC-MS, NMR and other methods to support impurity mass spectrometry research and the establishment of quality standards.

4.

Materials and fine chemicals synthesis: As a difunctional monomer containing ketals and aminooxy groups, it can be used for the design and synthesis of functionalized polyethers, crosslinking agents or special surfactants.

Safety Information

GHS Classification: GHS07, Signal word Warning (warning).

Core hazards: Harmful swallowing (H302); Causing skin irritation (H315); Causing severe eye irritation (H319); May cause respiratory tract irritation (H335).

Protection recommendations: operate in a fume hood or in a well-ventilated environment; wear nitrile gloves, chemical protective glasses and laboratory clothes; avoid dust/vapor inhalation; thoroughly clean the exposed parts after operation. In case of eye contact, rinse immediately with plenty of water for at least 15 minutes and seek medical attention; in case of skin contact, remove contaminated clothing and rinse with soapy water.

Storage and disposal: 2-8°C sealed and protected from light, away from oxidants, acids and fire sources; waste liquid shall be disposed according to local hazardous waste regulations and shall not be discharged into sewers.

Statement of scientific research use: This product is only for research and development and production purposes, and cannot be directly used for human or household purposes.

Why choose Shanghai Lizhuo Pharmaceutical-our advantages and production capacity

first, we can “catch” from gram-level screening to ton-level commercialization “. (4R)-2,2-dimethyl-[1,3] dioxolan-4-ylmethoxy amine (CAS 114778-50-6) is a conventional product of Shanghai Lizhuo Pharmaceutical, not the “for inquiry only” entry in the catalog. Whether customers need 100 mg samples in the early drug discovery stage or 100kg to ton batches to advance to the process scale-up stage, we can rely on our own R & D laboratory and pilot/production workshop to achieve stable delivery. The company has about 1,000 square meters of research and development laboratory, pilot and factory side with 100kg to ton production capacity, can cover from route screening, process optimization to scale-up production of the complete chain.

Second, the core of the chiral block is “batch consistency”, and we take this as the bottom line. The optical purity and impurity profile of hydroxylamine chiral intermediates directly determine the success or failure of downstream projects. Shanghai Lizhuo implements batch tracking and quality control of key chiral products from raw materials to finished products to ensure stable and controllable chiral purity, chemical purity and impurity distribution between different batches, so that customers’ process verification and registration declaration data can withstand repetition.

Third, response speed and communication efficiency are our differentiating competitiveness from large catalog suppliers. As the R & D and production entity in Shanghai under Shenzhen Rich Chemical Technology, we not only have the technology accumulation of our parent company in the field of fine chemicals, but also serve customers in a more flexible and project-oriented way. From technical consultation, specification confirmation to sample delivery and bulk quotation, we strive to give a clear answer in the shortest time, instead of letting customers spend time in the chain of “inquiry-transfer-waiting.

Fourth, compliance and intellectual property awareness run through. We are aware of the boundaries of the use of patent-protected compounds at the R & D stage, strictly enforce R & D use restrictions for patented products, and remind customers to comply with Chinese and destination laws in the sales process. This careful approach helps customers reduce compliance risks on the procurement side and reflects our professionalism as a long-term partner.

Welcome to visit our official website https://www.shlzpharma.com/ , View the complete product page of (4R)-2,2-dimethyl-[1,3] dioxolan-4-ylmethoxyamine (CAS 114778-50-6), or contact our technical sales directly The team obtains COA, samples and bulk quotations. If you are looking for a supply partner that can quickly transition from small samples to tons on chiral hydroxylamine blocks, with stable batches and no detours in communication, Shanghai Lizhuo Pharmaceutical is worth entering your short list of suppliers.