| Name | (4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid |
| Alias | (4S,5R)-2-(4-Methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-tert-butyl ester; side chain of Docetaxel; Docetaxel Side Chain; (4S,5R)-3-tert-butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic acid |
| CAS No. | 196404-55-4 |
| EINECS No. | 1592732-453-0 |
| chemical formula | C22H25NO6 |
| molecular weight | 399.44 |
| InChI | InChI=1S/C22H25NO6/c1-22(2,3)29-21(26)23-17(14-8-6-5-7-9-14)18(20(24)25)28-19(23)15-10-12-16(27-4)13-11-15/h5-13,17-19H,1-4H3,(H,24,25)/t17-,18+,19?/m0/s1 |
| InChIKey | MSVWUXLRSKRKFZ-PAMZHZACSA-N |
| density | 1.238g/cm³ (predicted 1.2±0.1g/cm³) |
| boiling Point | 573.8±50.0°C at 760 mmHg (predicted) |
| melting Point | 134-138°C |
| flash Point | 300.8±30.1°C |
| water soluble | almost insoluble in water, soluble in methanol, ethanol, DMSO and other organic solvents |
| vapor pressure | 5.25E-14 mmHg at 25°C (predicted) |
| refractive index | 1.567 (predicted value 1.568) |
| storage conditions | 2-8°C, sealed, dark, dry storage |
| sensitivity | sensitive to light and heat, sealed and stored at low temperature |
| appearance | white crystalline powder |
| specific Gravity | 1.238 |
| color | white |
| specific optical rotation | +34°(c=1 in CHCl₃) |
| MDL No. | MFCD09837613 |
| dangerous Goods Signs | Xn (harmful);GHS warning words: Warning (warning), pictograms: exclamation mark |
| risk Terms (R/H) | R22 Harmful if swallowed; R36/37/38 Irritating to eyes, respiratory system and skin; H302, H315, H319, H335 |
| security Terminology (S/P) | S24/25 Avoid contact with skin and eyes; P261, P264, P270, P280, P305 + P351 + P338, P501, etc. |
| Customs Number (HS) | 2934999090 (other heterocyclic compounds) |
nature of 1.
This product is a white crystalline powder with melting point 134-138 C, specific rotation +34 (c = 1, chloroform), clear chiral center (4S,5R configuration), molecular formula C22H25NO6, molecular weight 399.44,CAS No. 196404-55-4. The product is almost insoluble in water, soluble in methanol, ethanol, DMSO and other common organic solvents. The chemical structure contains a Boc-protected oxazolidine five-membered ring, which is a highly selective chiral side chain intermediate of docetaxel with high chiral purity and stable chemical properties.
2. uses
this product is an important pharmaceutical intermediate, mainly as docetaxel (Docetaxel, docetaxel) and cabazitaxel and other taxane anticancer drugs chiral side chain intermediates, widely used in laboratory research and development, API synthesis and industrial production. It can also be used in organic synthesis and chiral block research, and is one of the basic raw materials for semi-synthetic taxol products.
3. safety information
this product is a hazardous chemical (Xn), harmful if swallowed, irritating to eyes, skin and respiratory tract. Wear protective gloves, goggles and dust mask during operation to avoid inhalation of dust and contact with skin and eyes; clean thoroughly after operation. In case of contact with eyes, rinse immediately with plenty of water and seek medical attention. It should be stored sealed and protected from light at 2-8°C, away from heat sources and oxidizing agents; waste should be disposed of by qualified units in accordance with local regulations.
4. our production advantages and capacity
quality advantages: purity ≥ 99.0, chiral purity (ee value) is high, indexes such as heavy metals and residual solvents meet the intermediate standards of bulk drugs, and COA, HPLC chromatogram and detection method are provided with each batch of goods;
process advantages: has a mature continuous chiral synthesis process, short route, high yield, low cost, stable quality, small difference between batches;
capacity guarantee: large-scale production base, with an annual capacity of several tons, can stably supply orders from kg to 100kg, and can customize packaging specifications (1kg/25kg, etc.) according to customer needs;
service advantages: standing in stock, short delivery period, supporting the whole stage from small test, pilot test to commercial production, providing professional technical support and perfect after-sales guarantee.
welcome to visit our official website for more product details and cooperation information: https://www.shlzpharma.com/
Post time: Oct-26-2026
