List of basic product information
| Name | Ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate |
| Alias | Ethyl 5-amino-1-[(2-fluorophenyl)methyl]-1H-pyrazole-3-carboxylate; 1H-Pyrazole-3-carboxylic acid, 5-amino-1-[(2-fluorophenyl)methyl]-, ethyl ester |
| CAS No. | 256504-39-9 |
| EINECS No. | 805-733-7 |
| chemical formula | C₁₃H₁₄FN₃O₂ |
| molecular weight | 263.27 g/mol |
| InChI | InChI=1S/C13H14FN3O2/c1-2-19-13(18)11-7-12(15)17(16-11)8-9-5-3-4-6-10(9)14/h3-7H,2,8,15H2,1H3 |
| density | 1.29±0.1g/cm³(20°C,760 Torr, calculated); experimental value approx. 1.31g/cm³ |
| boiling Point | 451.9±40.0°C (predicted value); experimental value approx. 383°C |
| flash Point | approximately 227°C (experimental value) |
| water soluble | very slightly soluble, about 0.24g/L(25°C, calculated value); Experimental solubility about 2.57 × 10 in mol/L |
| vapor pressure | 0 Pa at 20°C (detected value); experimental vapor pressure about 5.10 × 10 but mmHg |
| refractive index | 1.59 (predicted/calculated) |
| storage conditions | 2-8°C, dark, dry |
| sensitivity | sensitive to light and moisture, dry and keep away from light |
| appearance | beige to yellow solid/powder |
| specific Gravity | approximately 1.29-1.31 (20°C compared to water) |
| color | off-white to yellow |
| MDL No. | MFCD20268229 |
| dangerous Goods Signs | irritant substance (GHS07: exclamation mark) |
| risk Terms | H315 (causes skin irritation);H319 (causes severe eye irritation) |
| safety terminology | P264 (clean thoroughly after work), P280 (wear protective gloves/eye mask/mask), P302 P352 (rinse with water after skin contact), P305 P351 P338 (rinse with water after eye contact) |
| customs Number | 2933199090 (other compounds containing unfused pyrazole ring) |
nature
the compound is a heterocyclic intermediate of fluorobenzyl substituted pyrazole carboxylic acid ethyl ester, which is white to yellow solid at room temperature. The molecule contains both amino, ester and fluorobenzyl groups, both lipophilic and polar functional groups. The density is about 1.29g/cm³, the flash point is high (about 227°C), the vapor pressure is extremely low, and the solubility in water is very small (about 0.24g/L), suggesting that it has limited dispersibility in conventional aqueous systems and is more suitable for participating in the reaction in organic solvent systems. It is sensitive to light and moisture during storage and should be sealed under dry conditions at 2-8°C in the absence of light.
Use
this product is a key synthetic intermediate of veliciguanide (Vericiguat) and lioxiguat (Riociguat) and belongs to the core pyrazole building block of the soluble guanylate cyclase (sGC) stimulator class of drugs. Villiseguanidine is used to treat heart failure with reduced ejection fraction. In its industrial synthesis route, the pyrazole intermediate and the subsequent fluoropyrazolopyridine intermediate (CAS 1361232-72-5) form the API skeleton together. Therefore, the product is mainly for API manufacturers, CDMO and pharmaceutical process research and development institutions, for the large-scale preparation and process optimization of velixozidine API.
Safety Information
according to the existing GHS classification, the substance is classified as skin irritation (Skin Irrit. 2,H315) and eye irritation (Eye Irrit. 2,H319). Wear protective gloves, goggles and face mask during operation to avoid dust inhalation and direct skin/eye contact; clean thoroughly after operation. First aid measures include rinsing with plenty of water after skin contact, rinsing with running water for at least 15 minutes after eye contact and seeking medical attention. The storage area should be kept cool, dark and dry, away from oxidizing agents and strong acid and alkali conditions. For more complete SDS first aid and handling information, please refer to the chemical safety technical instructions provided by ChemBlink and other databases.
Our production advantages and capacity
Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. (Shanghai Lizhuo Pharmaceutical Technology Co., Ltd.) lists CAS 256504-39-9 as a conventional large-scale production variety, which has a stable supply capacity from small-scale test samples to large-scale goods above ton level, and can meet the needs of CRO research and development, process amplification and API commercial production at different stages. This product and another key intermediate (CAS 1361232-72-5) form a matching intermediate supply combination, which helps downstream customers shorten the supply chain, reduce procurement coordination costs and improve process convergence efficiency on the same sGC stimulator project. The company has long focused on the process development and production of high-purity pyrazole heterocyclic intermediates, and has accumulated stable route amplification experience and batch quality control capability in the direction of fluorobenzyl pyrazole carboxylic acid esters, which can provide customers with continuous and traceable ton-level supply guarantee.
Welcome to visit our official website: https://www.shlzpharma.com/
Post time: Nov-01-2026
