List of Basic Product Information
| Name | Ethyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate |
| Alias | Vericiguat intermediate; Ethyl 5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carboxylate; 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester |
| CAS No. | 1361232-72-5 |
| chemical formula | C₁₆H₁₃F₂N₃O₂ |
| molecular weight | 317.29 g/mol |
| InChI | InChI=1S/C16H13F2N3O2/c1-2-23-16(22)14-12-7-11(17)8-19-15(12)21(20-14)9-10-5-3-4-6-13(10)18/h3-8H,2,9H2,1H3 |
| InChI Key | RTHPGICSOWFJBR-UHFFFAOYSA-N |
| density | 1.35±0.1g/cm³ (predicted) |
| boiling Point | 457.9±45.0°C(760 mmHg, predicted) |
| storage conditions | 2-8°C, protected from light, inert atmosphere |
| sensitivity | sensitive to light (Light sensitive) |
| appearance | white to light yellow powder |
| specific Gravity | approximately 1.35 (based on density predictions) |
| color | white to light yellow |
| dangerous Goods Signs | GHS07 (exclamation mark); signal word: warning (Warning) |
| risk Terms | H302 (harmful if swallowed);H315 (causes skin irritation);H319 (causes severe eye irritation);H335 (may cause respiratory irritation) |
| safety terminology | P280 (Wear protective gloves/protective clothing/goggles/face mask);P305 + P351 + P338 (If entering eyes: rinse carefully with water for a few minutes, if wearing contact lenses and can be easily removed, remove and continue to rinse) |
| customs Number | it is recommended to be classified as 2933.99 (other nitrogen-containing heterocyclic compounds); the actual declaration should be combined with the latest customs tariff and product form confirmation. |
Nature
this product is a fluorine-containing pyrazolo pyridine carboxylic acid ester derivative, which contains pyrazolo [3,4-b] pyridine condensed ring, 2-fluorobenzyl substituent and ethyl ester group. Solid at room temperature, literature and commercial information generally described as a white to light yellow powder. Density and boiling point are mainly based on the prediction model (density of about 1.35 g/cm, boiling point of about 457.9°C), the measured flash point, vapor pressure, water solubility and so on are still lack of public data. Storage requires low temperature (2-8°C), protection from light and isolation from oxygen or moisture to maintain the stability of the ester group and the fluorinated aromatic ring.
Use
this product is one of the key intermediates in the synthetic route of Vericiguat. Velicequine is a soluble guanylate cyclase (sGC) stimulator used in the treatment of chronic heart failure with reduced ejection fraction. In the process route of the drug, 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b] pyridine-3-carboxylic acid ethyl ester is used as a block with fluorobenzyl and pyrazolopyridine cores, and the target pharmacophore is introduced through subsequent conversion such as amidation/amination. In addition to villisetigat, the intermediate can also be used for fluorine-containing fused nitrogen heterocyclic ring related pharmaceutical chemistry exploration and custom synthesis.
Safety Information
according to the existing Safety Data Sheet (SDS), the substance is classified as acute oral toxicity (H302), skin irritation (H315), severe eye irritation (H319) and respiratory tract irritation (H335), and the GHS signal word is “Warning”. During operation, dust formation and inhalation should be avoided, and weighing and feeding should be carried out in a fume hood or an area equipped with local exhaust; protective gloves, goggles and protective clothing must be worn when touching. Rinse with soap and plenty of water immediately after skin contact, rinse with water for at least 15 minutes after eye contact and seek medical attention. Transport links are not normally classified as dangerous goods, but it is recommended that they be packaged and labeled according to laboratory or industrial chemical specifications. Wastes shall be handled by qualified professional disposal units and shall not be discharged into sewers.
Our production advantages and capacity
Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. (Shanghai Lizhuo Pharmaceutical Technology Co., Ltd.) focuses on the R & D and production of Vilexigua intermediates and characteristic pharmaceutical intermediates. Relying on our company’s fluorinated heterocyclic block technology platform, this product can realize scale-up from laboratory gram level to industrial 100kg to ton level, with conventional purity specification ≥ 98%(HPLC), and can provide customized purity and packaging specifications according to customer requirements. The production system has strict process parameter control and batch stability guarantee, which can provide innovative pharmaceutical companies and CDMO customers with full chain support from process development, impurity research to commercial supply. Welcome to visit the official website to learn more about products and production capacity details: https://www.shlzpharma.com/
Post time: Nov-01-2026
