In the specialized field of organic chemistry, the precision and efficiency of reactions are paramount. One reagent that stands out for its exceptional reactivity and reliability is Methyl Trifluoromethanesulfonate, commonly known as Methyl Triflate (CAS No. 333-27-7). As a premier methylating agent, this compound is indispensable for pharmaceutical companies and research institutions engaged in complex drug development.
At Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. , we understand the critical need for high-quality intermediates. As a subsidiary of Shenzhen Rich Chemical Technology Co., Ltd., we are dedicated to providing global partners with top-tier pharmaceutical intermediates and customized R&D services throughout the entire drug lifecycle—from early clinical research to market launch.
Product Overview: Chemical Identity and Physical Properties
Methyl Trifluoromethanesulfonate (CAS: 333-27-7) is a powerful alkylating reagent characterized by its strong electrophilic nature. Its chemical structure (linear formula: CF3SO2OCH3CF3SO2OCH3) consists of a methyl group attached to a triflate leaving group, making it one of the most reactive methyl esters available .
Key physicochemical properties of this compound include :
Molecular Formula: C2H3F3O3SC2H3F3O3S
Molecular Weight: 164.10 g/mol
Appearance: A colorless to yellow liquid.
Density: 1.45 g/cm³
Boiling Point: 94-99°C (201-210°F)
Flash Point: 38°C (100°F) – indicating flammability.
Refractive Index: n20/D 1.325 – 1.327
Due to its high reactivity and corrosive nature, it requires careful handling and storage under inert conditions, typically at refrigerated temperatures (2-8°C), to maintain its stability and efficacy .
Primary Applications and Market Demand
Methyl Triflate (333-27-7) is not just a laboratory reagent; it is a critical workhorse in industrial synthesis. Its primary role is as a highly efficient methylating agent, capable of transferring a methyl group to a variety of substrates, including alcohols, amines, phenols, and thiols .
Its key application areas include:
Pharmaceutical Intermediates: It is extensively used to synthesize complex Active Pharmaceutical Ingredients (APIs). Its ability to perform methylation reactions under mild conditions with high selectivity makes it invaluable for modifying biological molecules and creating drug candidates with enhanced stability and efficacy .
Agrochemicals and Material Science: Beyond pharmaceuticals, this reagent is utilized in the development of advanced materials and agrochemicals, where the introduction of a methyl group can significantly alter the properties of a molecule .
Fluorochemical Innovation: The trifluoromethanesulfonyl moiety in the molecule contributes to the creation of valuable fluorinated organic compounds, which are highly sought after for their unique electronic properties and chemical stability .
The global market for CAS 333-27-7 is driven by the continuous innovation in fluorochemicals and the growing demand for complex pharmaceuticals. Its role in enabling precise chemical transformations ensures a steady demand from major markets in Asia, Europe, and North America .
Why Choose Shanghai Lizhuo Pharmaceutical as Your Supplier?
Since our establishment, Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. has focused on bridging the gap between laboratory-scale research and commercial drug production. When you choose us as your partner for Methyl Triflate, you benefit from:
Technical Expertise in Custom Synthesis: We specialize in the R&D and customized production of pharmaceutical intermediates. Our team possesses deep technical knowledge to handle reactive reagents like Methyl Triflate, ensuring that our synthesis processes are optimized for safety and efficiency.
Robust Quality Assurance: Quality is non-negotiable in pharmaceutical development. Our R&D team leaders strictly formulate and monitor every step of the production process. We adhere to rigorous quality control standards to guarantee that our Methyl Triflate meets the high purity levels (typically ≥98%) required for sensitive downstream applications .
Scalable Production and Reliable Supply: Whether you need material for early-phase clinical trials or commercial production, our facility is equipped to scale accordingly. We are committed to providing a stable and consistent supply chain, mitigating the risks of supply disruptions for our global clients.
Full Lifecycle Support: As a subsidiary of Shenzhen Rich Chemical Technology Co., Ltd., we offer the resources and stability of an established chemical enterprise. We are not just a supplier; we are a development partner committed to supporting your project from the research phase through to drug listing.
Conclusion
Methyl Trifluoromethanesulfonate (CAS 333-27-7) is a powerful tool for chemists aiming to drive innovation in pharmaceutical and material science . With its superior reactivity and wide range of applications, securing a reliable source of this high-quality reagent is crucial for your project’s success.
Contact Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. today to discuss your requirements for CAS 333-27-7 or to learn more about our custom synthesis capabilities. Let us provide the chemical foundation for your next breakthrough.
Post time: Mar-19-2026
