Sodium Ethanethiolate (Cas No.811-51-8): A Key Fine Chemical Intermediate with Industrial-Grade Supply Advantages

Sodium Ethanethiolate (Cas No.811-51-8) is a vital anionic organic sulfur compound and a core intermediate in the fields of fine chemical synthesis, pharmaceutical manufacturing, and agrochemical production. With its strong nucleophilic reactivity and excellent chemical compatibility, it has become an irreplaceable raw material for the synthesis of a variety of fine chemicals and active pharmaceutical ingredients (APIs). Shanghai Lizhuo Pharmaceutical Technology Co., Ltd., a professional manufacturer of pharmaceutical intermediates and fine chemical products, has achieved large-scale, high-purity and stable production of Sodium Ethanethiolate. Relying on advanced synthesis technology, strict quality control and strong industrial production capacity, we provide high-quality products and customized supply solutions for global chemical, pharmaceutical and agrochemical enterprises, creating reliable value for the industrial chain partners.

I. Basic Identification and Physicochemical Properties of Sodium Ethanethiolate

1. Core Product Identification Information

English Name: Sodium Ethanethiolate; Sodium thioethoxide; Ethanethiol sodium saltCas Registration Number: 811-51-8Molecular Formula: C₂H₅NaSMolecular Weight: 84.12 g/molStructural Formula: CH₃CH₂SNaEINECS Number: 212-371-6

As a sodium salt derivative of ethanethiol, the product is formed by the reaction of ethanethiol with sodium hydroxide or metallic sodium, with a stable ionic structure and typical characteristics of alkali metal thiolate compounds, which lays a solid foundation for its wide application in organic synthesis reactions.

2. Key Physicochemical Properties

Sodium Ethanethiolate is a white to light yellow crystalline powder or flaky solid at room temperature, with strong hygroscopicity and high chemical reactivity, and its core physicochemical parameters and performance characteristics are as follows:

• Solubility: Easily soluble in polar solvents such as water, ethanol, methanol and dimethyl sulfoxide (DMSO); slightly soluble in non-polar organic solvents such as ether and benzene, and the aqueous solution is strongly alkaline, which can react with acids to generate ethanethiol;
• Melting Point: Decomposes at approximately 200℃ (no obvious melting point before decomposition), with good thermal stability under dry and anaerobic conditions, and is suitable for most organic synthesis reaction temperature ranges (0-150℃);
• Hygroscopicity and Reactivity: Strong hygroscopicity, easy to absorb moisture and agglomerate in the air, and easy to oxidize to generate disulfide compounds; it is a strong nucleophilic reagent, and can undergo nucleophilic substitution, condensation, cyclization and other reactions with a variety of organic halides, esters and carbonyl compounds, and the reaction selectivity is high;
• Storage and Transportation Requirements: It needs to be stored in a sealed, dry, anaerobic and cool environment (0-25℃), and isolated from water, acids, oxidants and air; it is packed in inert gas-filled sealed plastic drums or aluminum alloy drums, and transported in accordance with the transportation specifications of hazardous chemicals (corrosive and hygroscopic chemicals);
• Chemical Stability: Stable under dry and inert gas protection conditions, with a shelf life of up to 12 months; the decomposed products after moisture absorption are mainly sodium hydroxide and ethanethiol, which can be effectively controlled by reasonable storage and use operations.

3. Industrial Grade Quality Standards

Shanghai Lizhuo Pharmaceutical has formulated strict enterprise quality standards for Sodium Ethanethiolate (Cas No.811-51-8) in accordance with international industrial chemical production specifications and customer application requirements, and the product quality meets the high standards of pharmaceutical, agrochemical and fine chemical industries:

• Purity: Industrial grade ≥98.0%, pharmaceutical grade ≥95.0%, single impurity content ≤0.5%;
• Moisture Content: ≤0.5% (Karl Fischer method), effectively avoiding product agglomeration and decomposition caused by moisture absorption;
• Ash Content: ≤0.3%, ensuring the low impurity content of the product and no impact on the subsequent synthesis reaction;
• Heavy Metal Residues: Pb, As, Hg, Cd and other total heavy metals ≤10ppm, in line with the pharmaceutical and food additive raw material quality requirements;
• Reaction Activity: The nucleophilic reaction activity meets the industrial synthesis requirements, and the reaction conversion rate is ≥95% in the standard organic synthesis system.

II. Application Fields and Global Market Development of Sodium Ethanethiolate (Cas No.811-51-8)

As a classic strong nucleophilic reagent and organic sulfur intermediate, Sodium Ethanethiolate is widely used in organic synthesis reactions due to its high reactivity and good reaction selectivity. Its application covers pharmaceutical manufacturing, agrochemical synthesis, fine chemical production, rubber and plastic additives and other key industrial fields. With the continuous development of global pharmaceutical and agrochemical industries, the market demand for high-purity Sodium Ethanethiolate is showing a steady growth trend, and the industrial application value is constantly highlighted.

1. Core Application Fields

(1) Pharmaceutical Manufacturing: Key Intermediate for API Synthesis

Sodium Ethanethiolate is an important intermediate in the synthesis of a variety of clinical drugs and active pharmaceutical ingredients, and is widely used in the synthesis of antibacterial drugs, anti-tumor drugs, cardiovascular drugs and antiviral drugs. For example, it is used in the synthesis of cephalosporin antibacterial drugs to introduce thioethyl functional groups, optimize the drug’s antibacterial activity and pharmacokinetic properties; in the synthesis of some anti-tumor small molecule drugs, it is used as a nucleophilic reagent to construct the sulfur-containing heterocyclic structure of the drug molecule, which is the key step for the drug to exert its biological activity. In addition, it is also used in the synthesis of pharmaceutical intermediates such as thioether compounds and mercapto esters, providing important raw material support for the pharmaceutical R&D and production chain.

(2) Agrochemical Synthesis: Raw Material for Pesticides and Herbicides

In the agrochemical field, Sodium Ethanethiolate is the core raw material for the synthesis of a variety of high-efficiency, low-toxicity pesticides, herbicides and plant growth regulators. It is used to synthesize sulfur-containing pesticide active ingredients, such as organosulfur insecticides and herbicides, which can improve the pesticide’s adhesion, permeability and biological activity, and enhance the control effect on target pests and weeds. At the same time, it is also used in the synthesis of pesticide intermediates, realizing the structural modification and optimization of pesticide molecules, and meeting the market demand for green and efficient agrochemical products.

(3) Fine Chemical Production: Synthesis of Sulfur-Containing Fine Chemicals

It is widely used in the production of fine chemicals such as organic sulfur compounds, rubber additives, plastic modifiers and surfactant intermediates. As a sulfur source reagent, it is used to synthesize thioether, mercaptan, disulfide and other sulfur-containing fine chemicals, which are important raw materials for the production of rubber vulcanization accelerators, plastic heat stabilizers and anionic surfactants. In the fine chemical industry, the high purity and stable reactivity of Sodium Ethanethiolate are the key to ensuring the quality of downstream products, and it has become the first choice for many fine chemical enterprises.

(4) Organic Synthesis Research: Laboratory R&D Reagent

In the field of chemical research and development, it is a commonly used nucleophilic reagent in organic chemistry laboratories of universities, research institutes and enterprise R&D centers, and is widely used in organic synthesis reaction research, molecular structure modification, new material R&D and other fields. Its high reactivity and clear reaction mechanism make it an important research tool for exploring new organic synthesis routes and developing new chemical materials.

2. Global Market Development Status and Demand Trends

With the rapid development of global pharmaceutical, agrochemical and fine chemical industries, the market demand for Sodium Ethanethiolate (Cas No.811-51-8) is growing steadily, and the market development presents the following core characteristics and trends:

1. Steady growth of market demand: The global pharmaceutical market’s R&D and production of innovative drugs and generic drugs are booming, the agrochemical market is moving towards high efficiency, low toxicity and greenization, and the fine chemical industry is constantly upgrading and developing. These factors drive the annual compound growth rate of the global Sodium Ethanethiolate market to remain at 8%-12%, and the market scale continues to expand;
2. Increasing demand for high-purity products: With the continuous improvement of the quality requirements of downstream industries for raw materials, the demand for high-purity (≥99.0%) pharmaceutical grade and agrochemical grade Sodium Ethanethiolate is growing rapidly, while the market share of low-purity industrial grade products is gradually shrinking, and high-quality products have become the mainstream of the market;
3. Concentration of market demand: The global market demand for Sodium Ethanethiolate is mainly concentrated in North America, Europe, China, India and other regions with developed pharmaceutical and chemical industries. China has become an important production and consumption base of Sodium Ethanethiolate due to its complete chemical industry chain and strong manufacturing capacity;
4. Emphasis on green and environmentally friendly production: Global environmental protection policies are becoming increasingly strict, and chemical enterprises are required to adopt green and environmentally friendly synthesis processes, reduce three wastes (waste gas, waste water, industrial residue) emissions and improve resource utilization efficiency. Enterprises with green production technology and environmental protection certification will occupy a dominant position in the market competition;
5. Customized supply demand is prominent: Downstream customers have different requirements for the purity, particle size and packaging of Sodium Ethanethiolate according to different application scenarios. The market demand for customized products and personalized supply solutions is increasing, which puts forward higher requirements for the production and service capabilities of suppliers.

III. Production Advantages and Industrial Capacity of Sodium Ethanethiolate by Shanghai Lizhuo Pharmaceutical

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. has been deeply engaged in the R&D, production and sales of pharmaceutical intermediates and fine chemical products for many years, with strong technical R&D strength, advanced production equipment, strict quality control system and perfect industrial chain supporting capacity. For the production of Sodium Ethanethiolate (Cas No.811-51-8), we have formed core competitive advantages in synthesis technology, product quality, production capacity guarantee and after-sales service, and become a reliable supplier of global high-quality Sodium Ethanethiolate with stable and efficient industrial production capacity.

1. Technological Advantages: Independent R&D of Green and Efficient Synthesis Process

We have broken through the limitations of the traditional Sodium Ethanethiolate synthesis process, and independently developed a green, high-yield and low-consumption synthesis process with independent intellectual property rights, taking ethanethiol and high-purity sodium hydroxide as raw materials, through optimized reaction conditions, precise process control and high-efficiency purification technology to realize the industrial production of the product. Compared with the traditional process, our synthesis process has the following significant advantages:

• High reaction yield: The total reaction yield of the product is as high as 95% or more, which is far higher than the industry average of 85%, effectively reducing the production cost and raw material consumption;
• Green and environmental protection: Adopt closed reaction system and solvent recycling technology, the solvent recycling rate is ≥90%, reduce the discharge of organic waste liquid; the three wastes generated in the production process are treated by professional environmental protection equipment and reach the standard for discharge, in line with national environmental protection standards and global green chemical development trends;
• Stable process and high product quality: The whole production process adopts automatic DCS control system, realizing precise control of reaction temperature, pressure, time and other parameters, avoiding the influence of human factors on product quality, ensuring the stability of product purity and reactivity between batches, and the product qualification rate is 100%;
• Low impurity content: Adopt multi-stage purification technology such as recrystallization and vacuum drying, effectively remove impurities such as sodium hydroxide and disulfide, and the product purity can reach more than 99.0%, meeting the high-quality requirements of pharmaceutical and agrochemical industries;
• Strong scalability: The synthesis process has good scalability, which can realize seamless scale-up from laboratory small test (kg level) to industrial large production (ton level), and can quickly adjust the production scale according to market demand.

2. Quality Advantages: Full-Process Quality Control in Line with International Standards

Shanghai Lizhuo Pharmaceutical takes product quality as the core of enterprise development, and has established a complete quality management system (QMS) covering raw material procurement, production process, finished product inspection and storage transportation, which is in line with ISO9001 quality management system and GMP pharmaceutical production specifications, and strictly controls every link of Sodium Ethanethiolate production:

• Strict raw material procurement control: We have established a strict supplier qualification evaluation system, selected well-known domestic and foreign raw material suppliers with stable quality and strong strength, and conducted full-item inspection on all incoming raw materials (ethanethiol, sodium hydroxide, etc.), and only put them into production after passing the inspection, ensuring the high quality of raw materials;
• Real-time monitoring of production process: Set multiple quality inspection nodes in the production process, use high-performance liquid chromatography (HPLC), gas chromatography (GC) and Karl Fischer moisture meter to conduct real-time detection of the reaction intermediate and product quality, and adjust the process parameters in time according to the detection results to ensure the product quality meets the standards;
• Comprehensive finished product inspection: Before the finished product is put into storage, a full set of quality inspection is carried out in accordance with the enterprise quality standards, including purity, moisture content, ash content, heavy metal residues, reaction activity and other indicators. Only the products that pass all the inspections can be put into storage and sold, and a complete product inspection report is provided for each batch of products;
• Perfect quality traceability system: Each batch of Sodium Ethanethiolate has a unique batch number, which can realize the whole process traceability of raw material source, production process parameters, inspection data, storage and transportation information and sales destination, and quickly trace and handle quality problems if they occur, providing comprehensive quality assurance for customers.

3. Capacity Advantages: Large-Scale Industrial Production and Flexible Supply Capacity

We have built a modern fine chemical production base with advanced production equipment, reasonable workshop layout and complete supporting facilities, and set up specialized production lines for Sodium Ethanethiolate (Cas No.811-51-8) to realize the large-scale, continuous and automated production of the product, with strong production capacity guarantee and flexible supply capacity:

• Core industrial production capacity: The annual production capacity of Sodium Ethanethiolate of our company reaches 500 tons/year, which can fully meet the large-scale and continuous procurement needs of large domestic and foreign pharmaceutical, agrochemical and fine chemical enterprises;
• Flexible small-batch customization capacity: In addition to large-scale industrial production, we also have a professional small-batch production line, which can provide customized production services of 1kg-50kg for scientific research institutions, small and medium-sized enterprises and customers with trial production needs, with short production cycle and fast delivery speed;
• Sufficient inventory reserve: We have built a professional sealed storage warehouse with inert gas protection and constant temperature and humidity control, with a regular inventory reserve of 50-100 tons of Sodium Ethanethiolate, which can realize quick delivery and meet the emergency procurement needs of customers;
• Efficient logistics and distribution system: We have established long-term strategic cooperation with well-known domestic and foreign logistics enterprises, and have a complete hazardous chemical transportation network, which can realize domestic door-to-door delivery and international sea, air and land transportation. The product delivery time is short and the on-time delivery rate is 100%.

4. Service Advantages: One-Stop Customized Solution and Global Technical Support

Adhering to the service concept of “customer-centric, quality first, win-win cooperation”, we provide global customers with one-stop customized supply solutions and professional technical support for Sodium Ethanethiolate, and create a full-process service system from product procurement to application guidance:

• Customized product and packaging service: According to the different application scenarios, purity requirements and usage habits of customers, we can provide pharmaceutical grade, industrial grade and other different grades of Sodium Ethanethiolate products, and can customize the packaging specification (1kg/bag, 25kg/drum, 50kg/drum, etc.) and packaging material (plastic drum, aluminum alloy drum, vacuum sealed bag, etc.) according to customer needs;
• Professional technical support and service: We have a professional technical service team composed of senior chemical engineers and organic synthesis experts, who can provide customers with comprehensive technical support such as product application guidance, synthesis reaction process optimization, quality problem solution and safe use operation specification. The technical service team provides 7×24-hour online response, and can send technical personnel to the customer’s production site for on-site guidance if necessary;
• Long-term stable supply cooperation: For long-term cooperative customers, we formulate personalized long-term supply plans, lock in raw material costs and production capacity, ensure the stable supply of products, and avoid the impact of market price fluctuations and supply shortage on the customer’s production;
• Global market layout and localized service: We focus on the global market, and have established sales and service networks in North America, Europe, Southeast Asia, India and other major chemical and pharmaceutical markets, realizing localized product sales, logistics distribution and technical support, and providing convenient and efficient services for global customers.

IV. Enterprise Strength and Sustainable Development Commitment of Shanghai Lizhuo Pharmaceutical

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. is a subsidiary of Shenzhen Rich Chemical Technology Co., Ltd., with strong capital strength, advanced technical R&D capacity and perfect industrial production system. The company is mainly engaged in the R&D, production and sales of pharmaceutical intermediates, fine chemical products, small molecule building blocks and new drug reference substances, and is committed to providing global pharmaceutical companies and new drug R&D institutions with R&D and customized production services covering the entire life cycle of pharmaceutical intermediates from early clinical research to drug listing.

We have a professional R&D team composed of doctors, masters and senior engineers, and an organic chemical synthesis laboratory with advanced equipment. We focus on the R&D and process optimization of fine chemical intermediates and pharmaceutical raw materials, and have obtained a number of national invention patents and utility model patents. The company has successively passed ISO9001 quality management system, ISO14001 environmental management system and OHSAS18001 occupational health and safety management system certification, and the product quality has been highly recognized by domestic and foreign customers.

For Sodium Ethanethiolate (Cas No.811-51-8) and other fine chemical intermediate products, we will continue to increase R&D investment, further optimize the synthesis process, improve product quality and production capacity, and develop more high-value-added derivative products to meet the diversified market demand. At the same time, we will always adhere to the development concept of green and low-carbon, continue to upgrade the environmental protection production equipment and technology, reduce the environmental impact of production activities, and realize the sustainable development of the enterprise and the chemical industry chain.

As a reliable supplier of high-quality Sodium Ethanethiolate (Cas No.811-51-8), Shanghai Lizhuo Pharmaceutical is willing to work hand in hand with global customers in pharmaceutical, agrochemical and fine chemical industries, with high-quality products, advanced technology and perfect service, to create greater value for the development of the global chemical and pharmaceutical industry. If you have procurement needs, customized production requirements or technical consultation on Sodium Ethanethiolate (Cas No.811-51-8), please contact us through our official website, and our professional team will provide you with high-quality and efficient one-stop solutions!