2,2,2-Trifluoroethyl trifluoromethanesulfonate

I. Basic Product Information Table

II. Product Nature

Trifluoroethyl trifluoromethanesulfonate is a highly reactive fluorinated alkyl sulfonate compound with the following key characteristics:

Physical state: At room temperature, it is a colorless to pale yellow transparent liquid with low viscosity and high volatility.

Chemical activity: Contains a trifluoromethanesulfonate group (-OTf), which is a very strong leaving group and exhibits excellent electrophilic substitution activity, making it a highly efficient trifluoroethylating agent.

Stability: Stable under recommended storage conditions (2-8°C, sealed, inert atmosphere); sensitive to moisture, may decompose upon contact with water to produce trifluoromethanesulfonic acid and hydrogen fluoride.

Solubility: Slightly soluble in water, soluble in organic solvents such as chloroform and methanol.

Thermodynamic properties: Boiling point 89-91°C, density 1.611 g/mL (25°C), refractive index approximately 1.306, indicating high molecular density and good optical properties.

Safety characteristics: It is highly corrosive, acutely toxic, and inhalation toxic; strict protective measures are required during handling.

III. Product Uses

Trifluoroethyl trifluoromethanesulfonate is an important fine chemical intermediate and fluorine-containing synthetic reagent, with main applications including:

Pharmaceutical synthesis intermediates: widely used in the preparation of fluorinated drug molecules, especially in the synthesis of fluorinated amino acids such as nitrophenylalanine via phase transfer catalytic alkylation reactions.

Trifluoroethylating agents: As potent electrophilic trifluoroethylating agents, they are used to introduce trifluoroethyl (CF₃CH₂-) groups into organic molecules, enhancing the metabolic stability and lipophilicity of drugs.

Organic synthesis reagents: used to prepare nitrogen-containing heterocyclic compounds such as cyclic N-arylhydroxamic acids, playing an important role in asymmetric synthesis.

Lithium-ion battery electrolytes: functional additives that can be used as electrolytes in lithium-ion batteries to improve the battery’s electrochemical performance and safety.

Pesticide and Material Intermediates: Key intermediates in the synthesis of fluorinated pesticides, high-performance fluorinated materials, and specialty surfactants.

IV. Security Information

4.1 Hazard Overview

Signal word: Danger

Major hazards: poisonous when swallowed (H301), causes severe skin burns and eye damage (H314), fatal when inhaled (H330)

Hazard categories: Acute toxicity (inhalation category 2, oral category 3), skin corrosion (category 1B)

4.2 Protective Measures

Respiratory protection: Wear a gas mask or positive pressure self-contained breathing apparatus (P284).

Eye protection: Wear chemical safety goggles/face shield.

Skin protection: Wear corrosion-resistant protective clothing, acid and alkali-resistant gloves, and protective boots.

Operating environment: Operate only in fume hoods or well-ventilated areas (P271), avoid inhalation of vapors or aerosols (P260).

Hygiene measures: Wash hands thoroughly after the procedure (P264); refrain from eating, drinking, and smoking during the procedure (P270).

4.3 First Aid Measures

Inhalation: Immediately move the patient to a place with fresh air, keep the airway open, perform artificial respiration if necessary, and seek medical attention immediately (P304+P340).

Skin contact: Immediately remove all contaminated clothing, rinse with plenty of running water for at least 15 minutes, and seek medical attention (P303+P361+P353).

Eye contact: Immediately flush with running water or saline solution for at least 15 minutes, remove contact lenses (if easily removable), continue flushing, and seek medical attention (P305+P351+P338).

If ingested: Rinse mouth immediately, do not induce vomiting, and immediately call a poison control center or seek medical attention (P301+P330+P331).

4.4 Storage and Transportation

Storage conditions: Store in a cool, dry, well-ventilated dedicated warehouse at a temperature of 2-8°C; keep away from oxidizers, alkalis, and heat sources; keep containers tightly closed and protected under an inert atmosphere.

Transport classification: UN 3265, Class 8 Corrosive substances, Packing category II

Leakage Handling: Wear full protective gear, collect the leaked material with inert absorbent material, and transfer it to a designated waste container.

V. Our Company’s Production Advantages and Capacity

5.1 Core Production Advantages

High purity process control

Product purity ≥99.0% (GC), with strict impurity control (trifluoromethanesulfonic anhydride <1.0%, sulfate ≤50 ppm, fluoride ≤50 ppm).

Equipped with advanced fluorination reaction equipment and distillation purification system, ensuring batch-to-batch quality stability.

Professional technical team

Master the core synthesis process and purification technology of trifluoromethanesulfonate compounds

Provide full technical support from laboratory scale to industrial scale-up.

Strict quality management system

1)

Customized service capabilities

Supports multiple packaging sizes: 100g, 1kg, 25kg, 200kg, and ton-level packaging.

We can provide products with different purity grades (97%, 98%, 99%) according to customer needs.

Inert atmosphere packaging (nitrogen/argon protection) is available to meet the special needs of moisture-sensitive products.

2)

Supply chain stability

The key raw materials, trifluoromethanesulfonic acid and trifluoroethanol, must be independently controlled or a long-term strategic partnership must be established.

Establish a safety stock mechanism to ensure continuous supply to global customers.

5.2 Production Capacity

Our company has a dedicated fluorination reaction workshop equipped with glass-lined and Hastelloy reactors (capacity 500L to 3000L), with a designed annual production capacity of 50 to 100 tons, which can be expanded to 200 tons/year according to market demand. The packaging line uses automated filling equipment, supporting various packaging forms such as glass bottles, fluorinated bottles, stainless steel drums, and IBC containers.

Regarding delivery time, small orders (100kg and below) can be delivered within 3 to 5 working days, while large orders (1 ton and above) have a delivery time of approximately 2 to 3 weeks. Finished product storage utilizes a constant temperature cold storage of 2 to 8°C, with inert gas protection and explosion-proof design to ensure the stability and safety of products during storage.

Please contact us if you require samples.