Product Overview: High-Purity Functional Pyridine Derivative
4-Amino-5-Methylpyridin-2-ol is a high-purity pyridine derivative that appears as a white to light yellow crystalline solid. It demonstrates excellent solubility in common organic solvents such as ethanol and dimethylformamide (DMF), as well as strong thermal stability and chemical reactivity.
From a structural perspective, the molecule contains three highly reactive functional groups:
- · Amino group (-NH₂)
- · Hydroxyl group (-OH)
- · Methyl substituent (-CH₃)
This combination of functional groups provides multiple reactive sites on the pyridine ring, enabling diverse chemical transformations such as substitution reactions, coupling reactions, and heterocyclic construction.
Because of these properties, 4-Amino-5-Methylpyridin-2-ol is widely recognized as a versatile intermediate for pharmaceutical synthesis, fine organic chemistry, and dye manufacturing. Its stability and reactivity balance also make it suitable for scalable industrial applications.
In the rapidly evolving global pharmaceutical and fine chemical industries, the demand for high-purity, multifunctional heterocyclic intermediates continues to grow significantly. Among these critical compounds, 4-Amino-5-Methylpyridin-2-ol (CAS No. 95306-64-2) has emerged as an important building block widely used in pharmaceutical synthesis, fine organic chemistry, and specialty chemical manufacturing.
Driven by the expansion of chronic disease therapies, precision medicine, and high-performance material development, this pyridine-based intermediate is playing an increasingly strategic role in modern industrial chemistry. Its unique molecular structure and versatile reactivity make it indispensable in both research and large-scale production environments.
Key Applications and Industry Demand
1. Intermediate for Finerenone (nsMRA Drug Synthesis)
One of the most important applications of 4-Amino-5-Methylpyridin-2-ol is its role as a key intermediate in the synthesis of Finerenone, a novel non-steroidal mineralocorticoid receptor antagonist (nsMRA).
Finerenone is widely used in the treatment of chronic kidney disease associated with type 2 diabetes and cardiovascular complications. As global prevalence of these conditions continues to rise, demand for more effective and safer therapeutic solutions is increasing rapidly.
To support large-scale pharmaceutical production, manufacturers require highly pure and stable intermediates that ensure:
- · High reaction selectivity
- · Improved synthetic efficiency
- · Reduced impurity formation
- · Scalable manufacturing processes
4-Amino-5-Methylpyridin-2-ol plays a crucial role in enabling efficient molecular construction in Finerenone synthesis pathways. It supports selective functionalization steps, helping improve overall yield and product quality in industrial pharmaceutical processes.
2. Fine Organic Synthesis and Medicinal Chemistry Applications
Beyond pharmaceutical manufacturing, this compound is widely used in fine organic synthesis and medicinal chemistry research.
Its multifunctional structure makes it a valuable “building block molecule” for constructing complex heterocyclic systems. The presence of both nucleophilic (amino, hydroxyl) and aromatic (pyridine) functionalities allows it to participate in a wide range of chemical reactions.
Common applications include:
- · Drug discovery and lead compound optimization
- · Agrochemical intermediate development
- · Advanced heterocyclic compound synthesis
- · Functional material research
- · Laboratory-scale organic transformations
In modern green chemistry and efficient synthesis design, such multifunctional intermediates are essential for improving atom economy and reducing synthetic steps. This contributes to more sustainable and cost-effective chemical manufacturing processes.
3. Dye and Specialty Chemical Industry Applications
The dye and pigment industry also represents an important application area for pyridine derivatives such as 4-Amino-5-Methylpyridin-2-ol.
These compounds are widely used in the production of:
- · Textile dyes
- · Industrial coatings
- · Printing inks
- · Functional color materials
The chemical structure of this intermediate contributes to improved:
- · Color stability
- · Thermal resistance
- · Lightfastness
- · Molecular binding performance
As global industries move toward high-performance and environmentally stable dye systems, demand for advanced intermediates continues to grow. This compound supports the development of next-generation dye materials with enhanced durability and application versatility.
Global Market Insights and Growth Drivers
The global market for pharmaceutical intermediates and fine chemicals is experiencing steady growth, driven by several key macroeconomic and industrial factors:
- · Rising prevalence of chronic diseases such as diabetes and cardiovascular disorders
- · Increasing investment in pharmaceutical R&D and drug discovery
- · Expansion of precision medicine and targeted therapy development
- · Growing demand for high-purity intermediates in industrial synthesis
- · Shift toward sustainable and efficient chemical manufacturing processes
Within this context, high-functionality pyridine derivatives like 4-Amino-5-Methylpyridin-2-ol are becoming increasingly important due to their adaptability in multiple industrial applications.
The need for reliable, scalable, and high-purity chemical intermediates is expected to continue rising as pharmaceutical companies optimize synthesis routes and improve production efficiency.
Manufacturing Excellence: Shanghai Lizhuo Pharmaceutical Technology Co., Ltd.
Long-term strategic partnerships have been established with multiple high-quality raw material suppliers both domestically and internationally, ensuring a stable supply of key raw materials. A complete warehousing and logistics system enables rapid response and timely delivery. (5) Customization Service: We can provide products of different specifications and purity levels (from 95% to 97%) according to customer needs, supporting customized production from gram-level to ton-level. We also provide impurity reference standards, standard products, and related technical data support. 6.2 Production Capacity
Current Capacity: 50 tons/year of fenelazol intermediates
Planned Capacity: 100 tons/year after Phase II expansion
Packaging Specifications: 1g, 10g, 50g, 100g, 500g, 1kg, 5kg, 10kg, 25kg/drum
Delivery Time: 3-5 working days for standard specifications; 15-30 working days for bulk orders
6.3 Certifications
ISO 9001 Quality Management System Certification
ISO 14001 Environmental Management System Certification
Drug Production License
Application for Certificate of Enzyme Extract (CEP) for Export to EU (underway)
DMF Filing (US FDA)
6.4 Application Areas
Our fenelazol intermediates are widely used in:
Fenelazol API synthesis
Generic drug consistency evaluation research
Impurity research for new drug registration applications
Medicinal chemistry research in research institutes
CRO/CDMO project cooperation
1. Advanced Synthetic Technology
The company employs optimized synthetic routes and modern production systems to ensure high yield, excellent purity, and minimal by-product formation. This guarantees that products meet stringent pharmaceutical-grade standards.
2. Strict Quality Control System
All products undergo comprehensive analytical testing, including HPLC, NMR, and mass spectrometry analysis. This ensures:
- · Accurate chemical identity
- · Stable purity levels
- · Batch-to-batch consistency
- · Reliable performance in downstream applications
3. Scalable Industrial Production
With strong manufacturing capacity, the company can support both small-scale R&D supply and large-scale commercial production. This ensures uninterrupted supply chains for global customers in pharmaceuticals and specialty chemicals.
4. Professional Technical Support
In addition to manufacturing, the company provides technical services such as:
- · Process optimization guidance
- · Custom synthesis solutions
- · Application support for chemical development
- · Collaboration with R&D teams for efficiency improvement
This integrated approach enhances customer productivity and accelerates product development cycles.
As global demand for advanced intermediates continues to rise, this compound plays an increasingly critical role in supporting innovation across pharmaceuticals and chemical manufacturing sectors.
Through advanced production capabilities, strict quality assurance systems, and professional technical support, Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. is committed to providing reliable access to high-quality intermediates. This enables global customers to improve efficiency, enhance product quality, and accelerate innovation in pharmaceutical and fine chemical development.
Post time: Jun-23-2026
