4-Bromo-3-fluoro-2-methylaniline

1. product basic information table

2. product nature

4-bromo -3-fluoro -2-methyl aniline (CAS: 127408-03-1) is a halogenated aromatic amine compound with the molecular formula C712 H-BrFN and a molecular weight of 204.04. Three substituents of bromine, fluorine and methyl are introduced into the aniline skeleton at the same time, forming a “trifunctional group” structure: amino group can participate in amidation, sulfonamidation and diazotization reactions; bromine atom is an ideal active site for Suzuki, Buchwald and other coupling reactions; fluorine atom can significantly improve the metabolic stability of downstream products; ortho methyl group provides steric hindrance and conformational control ability. With a predicted boiling point of 244.5±35.0°C, a density of 1.589g/cm³, and a pKa of 2.73±0.10 (about 4.6 below that of aniline), it exhibits a unique pH-dependent behavior in acidic aqueous extraction separations. The product is a pink to off-white crystalline solid, stable on storage at 2-8°C in the dark.

3. product use

1.

Pharmaceutical intermediate: This product is the key to the oral GLP-1 receptor agonist Oglerone (Orforglipron)

synthetic intermediate, also included in the Pharmacopoeia standard system as “Orforglipron impurity 30″ (Ogleron impurity 30), used for quality control and impurity research of the API.

2.

Organic synthesis block: as bromo-fluoro-methyl trisubstituted aniline, it is widely used in multi-step synthesis in the fields of medicine, pesticide and functional materials, especially suitable for pharmaceutical chemistry research requiring bromine/fluorine/amino sequential orthogonal functionalization.

3.

Analytical reagents and standards: used in the fields of analysis and detection, impurity reference substances and export trade.

4. safety information

this product is a toxic organic solid, dangerous goods transport number UN2811. Wear protective gloves, goggles and dust mask during operation to avoid inhalation of dust and contact with skin and eyes. In case of accidental contact, rinse with plenty of water immediately and seek medical treatment. Store in a cool, ventilated and dry warehouse at 2-8°C, sealed and protected from light, away from heat sources, open flames and strong oxidants. Waste shall be disposed of by qualified units in accordance with local regulations. Complete MSDS can be supplied with the shipment.

5. our production advantages and capacity

1.

Capacity guarantee: the company has a compliant production workshop, support 100kg to ton-level stable supply), spot and custom production in parallel.

2.

Quality advantage: purity ≥ 99%(HPLC), COA is provided for each batch, and a complete set of detection maps such as NMR, HPLC, GC, LC-MS, etc. As a supporting intermediate of Ogleron project, the impurity control system is perfect, and it supports customer audit and registration application documents (DMF/CEP support).

3.

Process and cost advantages: the self-developed bromination-fluorination continuous process has high yield, less three wastes and obvious competitiveness in cost compared with peers. Support 1kg/10kg/25kg/100kg variety of packaging specifications, can be packaged according to customer requirements.

4.

Compliance and delivery: with export qualification, complete qualification for dangerous goods transportation, rich experience in global logistics and distribution, and stable delivery.

Whether you are in the early route exploration, process validation or commercial supply stage, we can provide you with the right quality level and supply plan.