4-Cyanide -2-methoxy benzaldehyde

1.nature

4-cyano -2-methoxy benzaldehyde is a substituted aromatic aldehyde, benzene ring at the same time attached to the aldehyde group (-CHO), methoxy (-OCH) and cyano (-CN) three functional groups. This structure gives it high reactivity and diverse conversion possibilities.

In terms of physical properties, it is a high-boiling, low-volatile solid with a melting point of 109-111°C, a boiling point of 318.2°C(760 mmHg), a flash point of 138.3°C, a density of about 1.18g/cm³, and a very low vapor pressure at 25°C (about 0.000368 mmHg). Solubility performance for slightly soluble in water, soluble in ethanol, acetone, dichloromethane, ethyl acetate and other common organic solvents. LogP is about 1.25-1.42, with a certain degree of lipophilicity.

In terms of chemical stability, the compound itself is relatively stable under conventional conditions, but it is sensitive to air and needs to be stored at low temperature (2-8°C) under the protection of inert gas to avoid side reactions such as aldehyde group oxidation.

2. uses

core application: Key intermediates of nonneridone (Finerenone). Developed by Bayer, fenelidone is the world’s first non-steroidal selective mineralocorticoid receptor antagonist (MRA), approved by FDA in 2021 for the treatment of adult patients with chronic kidney disease (CKD) associated with type 2 diabetes, which can significantly reduce the risk of sustained eGFR decline, end-stage renal disease, cardiovascular death and heart failure hospitalization. 4-cyanide -2-methoxy benzene formaldehyde in the synthesis of the drug as an aromatic side chain building block, through the introduction of aldol condensation 4-cyanide -2-methoxy phenyl, and then through the double bond reduction, ethyl, amidation and other steps to build non-nelidone API.

Other application directions:

pharmaceutical intermediates: used for the synthesis of a variety of drug molecules containing dihydropyridine structure; cyano can be converted into carboxylic acid, amide and other functional groups, is an important building block for the synthesis of tyrosine kinase inhibitors and other bioactive molecules.

Fine chemical synthesis: as a bifunctional aromatic block containing both cyano and aldehyde groups, it participates in a variety of organic transformations such as Knoevenagel condensation, reductive amination, Grignard reaction, etc.

Pesticide intermediates: used to construct new active pesticide molecules.

Materials science: as synthetic precursors for functional aromatic compounds.

3. safety information

hazard classification: Hazardous goods are marked as Xi (irritant articles), risk term R43 (possible sensitization in contact with skin), safety term S36/37 (wearing appropriate protective clothing and gloves). In the GHS classification, some data sources are labeled as H318 (causing severe eye injury) or H302 (swallowing harmful), which is subject to the actual batch MSDS.

Operation precautions: should be operated in the fume hood, wear protective gloves, goggles and respirators, avoid inhalation of dust, away from fire and heat sources. Incompatible substances include strong oxidants, strong acids, strong bases.

First aid measures:

inhalation: Move to fresh air.

Skin contact: remove contaminated clothing and wash thoroughly with soap and water.

Eye contact: Flush with running water or saline and seek medical attention immediately.

Ingestion: gargle, do not induce vomiting, seek medical attention immediately.

Storage and transportation: 2-8°C, sealed storage under the protection of inert gas, away from oxidants and acid and alkali substances. The goods are not dangerous goods (DOT/IATA) and can be transported as general chemicals.

4. our production advantages and capacity

shanghai Lizhuo Pharmaceutical Technology Co., Ltd. (Lizhuo Pharmaceutical) has long focused on the research and development, production and sales of pharmaceutical intermediates, and has the complete ability from research and development samples to tons of commercial supply on 4-cyanide-2-methoxybenzaldehyde.

(I) capacity scale

the product has an annual production capacity of more than 10,000kg, which can meet the bulk procurement needs of large pharmaceutical companies at home and abroad, and supports full specification coverage from gram-level research and development samples, kilogram-level pilot to ton-level commercial production. The production system has a variety of reaction capabilities such as bromination, high pressure, high temperature (250°C), low temperature (− 78°C), Grignard reaction, Suzuki reaction, etc., with a total reaction capacity of 210000 liters, providing hardware guarantee for large-scale and stable supply.

(II) quality indicators

the conventional purity is ≥ 98%(HPLC) , and the specification of ≥ 99% can be customized. The single impurity is controlled below 0.1, which meets the quality control requirements of the starting materials of API. COA and MSDS are provided for each batch to support third-party testing and verification.

(III) process and cost

the optimized multi-step synthesis process is used, the reaction conditions are mild, the yield is high, the waste emission is low, the key intermediate process is controllable, and the supply chain is stable. Relying on its own production base and stable raw material procurement channels, large-scale production significantly reduces unit costs and has clear price competitiveness at the same quality level.

(IV) Compliance and Delivery

the manufacturing facility complies with GMP requirements and has a complete EHS management system to assist customers in completing the initial material audit required for API registration. Standing inventory is sufficient, domestic customers 3-5 working days, international customers 7-15 working days can be delivered, support air and sea and other logistics methods. Professional R & D team can provide synthetic route consulting, impurity spectrum analysis, analysis method development and other technical services.

Welcome to visit our official website to obtain the latest specifications, inventory and quotation information of this product: https://www.shlzpharma.com/