| Name | 4,6-Dihydroxypyridazine-3-carboxylic acid |
| Alias | 4-Hydroxy-6-oxo-1,6-dihydropyridazine-3-carboxylic acid; EOS-61508; Deucravacitinib Impurity 9; BMS-986165 Related Compound 4; 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylic acid; 3-Pyridazinecarboxylic acid, 1,6-dihydro-4-hydroxy-6-oxo- |
| CAS No. | 1442437-21-9 (some documents are also included in CAS 1823277-97-9) |
| chemical formula | C₅H₄N₂O₄ |
| molecular weight | 156.10 |
| InChI | InChI=1S/C5H4N2O4/c8-2-1-3(9)6-7-4(2)5(10)11/h1H,(H,10,11)(H2,6,8,9) |
| density | 1.88±0.1g/cm³ (predicted) |
| melting Point | 232-234°C (literature values) |
| storage conditions | store in a sealed and dry place at room temperature (Sealed in dry, Room Temperature); Long-term storage is recommended to be 2-8°C |
| sensitivity | sensitive to humidity (molecules containing carboxyl and hydroxyl groups, easy to absorb moisture, need to seal moisture) |
| appearance | solid powder |
| specific Gravity | about 1.88 (predicted value, same density) |
| color | Off-white to yellow |
| dangerous Goods Signs | Xi (irritant) |
| risk Terms | H315 (causes skin irritation);H319 (causes severe eye irritation);H335 (may cause respiratory irritation) |
| safety terminology | P261 Avoid inhalation of dust; P264 Clean thoroughly after operation; P280 Wear protective gloves/goggles; Rinse with plenty of water for skin contact of P302 + P352; Rinse with eye contact of P305 + P351 + P338 for at least 15 minutes; P403 + P233 Store in airtight and ventilated place |
| customs Number | 2933990090 (other heterocyclic compounds, for reference only, subject to actual declaration classification) |
1. product nature
4,6-dihydroxypyridazine-3-carboxylic acid (CAS 1442437-21-9) is a pyridazine heterocyclic compound with the molecular formula CYHWH and 156.10 molecular weight. Its structure is based on the pyridazine ring as the core, with a hydroxyl group attached to the 4 and 6 positions (ketone tautomerism exists at the 6 position, so it is also called 4-hydroxy -6-oxo -1,6-dihydropyridazine -3-carboxylic acid), and a carboxylic acid group is attached to the 3 position. Abundant hydrogen bond donors/acceptors make them highly polar and chemically active, and are important building blocks for organic synthesis. The product is a white to yellow solid powder with a melting point of 232-234°C and a predicted density of about 1.88g/cm³. It should be sealed against moisture and stored at room temperature. As a related compound 4 of BMS-986165(Deucravacitinib, deuterated lenxitinib/declavatinib), this product is also a commonly used impurity reference substance in the quality study of this drug.
2. product use
pharmaceutical intermediates: are the key starting materials/intermediates for the synthesis of JAK/TYK2 inhibitor drugs such as Deucravacitinib and BMS-986165, and the structure of the pyridine mother nucleus is constructed by chlorination, amidation and other steps;
·
Impurity reference substance: as Deucravacitinib Impurity 9 (declavatinib impurity 9), used for quality research, impurity spectrum analysis and methodology verification of API and preparation;
organic synthetic blocks: used to build more complex heterocyclic compounds, used as active skeletons in pharmaceutical chemistry, pesticide chemistry and functional materials research and development;
research reagents: for universities, research institutes and enterprise research and development laboratories for new drug screening and structure-activity relationship research.
3. safety information
this product is an irritant solid (Xi). Dust exposure may cause skin irritation (H315), severe eye irritation (H319) and respiratory tract irritation (H335). The operation should be carried out in the fume hood, wear protective gloves, chemical goggles and dust mask; avoid inhalation of dust, contact with skin and eyes; if careless contact, immediately rinse with plenty of water and seek medical treatment in time. The product should be sealed and stored in a dry and ventilated place, away from oxidants and strong acids and alkalis; the waste liquid should be disposed of by professional institutions according to local regulations. This product is only for scientific research and industrial use, not suitable for human body.
Our production advantages and capacity
1.
Stable mass production capacity: 4,6-dihydroxypyridazine -3-carboxylic acid (CAS 1442437-21-9) is a conventional variety produced by our company all the year round. Small samples of gram grade can be officially supplied to large quantities of tons, with a monthly production capacity of more than tons, and can undertake long-term stable supply contracts;
2.
Strict quality control: each batch of products are provided with HPLC purity test report (conventional purity ≥ 98%, 99% high purity specifications can be customized according to customer requirements), and equipped with NMR, LC-MS and other structural confirmation data, impurity control in line with ICH Q7 API standard;
3.
Mature process and controllable cost: the self-optimized synthetic route has mild reaction conditions, high yield, less waste, obvious scale and cost advantages, and can provide customers with competitive prices;
4.
Perfect service system: from sample provision, technical consultation to logistics and distribution, support customized packaging and compliance export documents, fast response and reliable delivery.
Welcome to visit our official website for more product information and cooperation details:
https://www.shlzpharma.com/
Post time: Oct-26-2026
