1. product basic information table
| Name | 5-Bromo-4-fluoro-1H-indazole |
| Alias | 1H-Indazole, 5-bromo-4-fluoro-; 5-Bromo-4-fluoro-indazole; 5-bromo-4-fluoro(1H)indazole |
| CAS No. | 1082041-85-7 |
| chemical formula | C₇H₄BrFN₂ |
| molecular weight | 215.02 g/mol |
| InChI | InChI=1S/C7H4BrFN2/c8-5-2-7-4(1-6(5)9)3-10-11-7/h1-3H,(H,10,11) |
| InChIKey | YJOQUFUSNSCGHN-UHFFFAOYSA-N |
| SMILES | Fc1c(Br)ccc2[nH]ncc12 |
| density | approximately 1.9 g/cm (predicted) |
| boiling Point | 332.2±22.0°C @ 760 mmHg (predicted) |
| flash Point | 154.7±22.3°C (predicted) |
| water soluble | no public measured data; Soluble in DMSO, DMF and other organic solvents |
| vapor pressure | very low (predicted value, approaching 0 mmHg at 25°C) |
| refractive index | approximately 1.693 (predicted) |
| storage conditions | sealed and stored in a cool, dry, dark place, stored at room temperature |
| sensitivity | insensitive to moisture; avoid contact with strong oxidants |
| appearance | white to off-white crystalline powder/solid |
| specific Gravity | approximately 1.9 (predicted) |
| color | white to off-white (yellowish) |
| MDL No. | MFCD11007927 |
| dangerous Goods Signs | Xi (irritant), subject to actual SDS |
| risk Terms | R36/37/38 (Irritating to eyes, respiratory system and skin), subject to actual SDS |
| safety terminology | S26-S36/37/39 (Rinse immediately after contact with eyes, wear appropriate protection), subject to actual SDS |
| customs Number | HS 2933990090 (other heterocyclic compounds, subject to customs classification) |
2.nature
5-Bromo-4-fluoro-1H-indazole is a halogen-substituted indazole heterocyclic compound, which is formed by the fusion of benzene ring and pyrazole ring, and the 5-position bromine atom is substituted adjacent to the 4-position fluorine atom, forming a unique electron distribution structure. The molecular formula is C, H, BrFN₂ has a molecular weight of 215.02, a polar surface area (PSA) of 28.68 Ų, and a lipid-water partition coefficient LogP of about 2.56. The bromine atom in the molecule is an excellent leaving group, which can be used as an active site for cross-coupling reactions such as Suzuki coupling and Buchwald-Hartwig amination. The strong electronegativity of the fluorine atom gives it unique reaction selectivity and metabolic stability, and is an important “structure-activity regulatory group” in the design of drug molecules “.
3. Uses
5-Bromo-4-fluoro-1H-indazole is an important pharmaceutical intermediate and building block of medicinal chemistry. Indazole skeleton widely exists in the molecular structure of kinase inhibitors, anti-tumor drugs and GLP-1 receptor agonists. This product can introduce aryl, heteroaryl or amine side chains through Suzuki coupling, carbon-nitrogen coupling and other reactions at the bromine atom site, and can also be selectively functionalized by the proximity effect of fluorine atoms for synthesis:
antitumor drug intermediates of protein kinase inhibitors;
small molecule GLP-1 receptor agonists (such as Ogleron Orforglipron series) key intermediates 5-bromo-4-fluoro-1-methyl-1H-indazole nucleus;
PROTAC molecular degrader linker arm fragment;
other fluorine-containing, bromine-containing heterocyclic drugs and pesticide intermediates.
4. Safety Information (Safety Information)
this product is a chemical, only for scientific research and industrial production purposes, non-medicinal, non-edible. It is recommended to wear protective gloves, goggles and dust mask during operation to avoid inhalation of dust and contact with skin and eyes. If accidentally contacted, rinse with plenty of water immediately and seek medical treatment. Store in a sealed container in a cool, dry and dark place, away from fire, heat and strong oxidants. Waste disposal shall comply with local environmental regulations. The specific hazard classification, transportation information and complete disposal plan are subject to the accompanying SDS (Safety Data Sheet).
5. our production advantages and capacity
as a professional manufacturer of 5-bromo-4-fluoro-1H-indazole, our company has the following core advantages:
1.
Source factory, independent production: with independent production workshop and mature process route, from raw materials to finished products can be controlled, non-traders, price and delivery date are more competitive.
2.
Stable and reliable quality: the purity of the product is stable (routine ≥ 98%, which can be customized to more than 99% according to customer’s requirements). Each batch provides a complete set of detection data such as HPLC, LCMS, NMR and COA certificates, and the quality is controllable and traceable.
3.
Adequate production capacity: annual production capacity of tens of tons, kg to ton orders can be quickly responded to, 100kg stock standing, to meet the needs of all stages from research and development to commercial production.
4.
Custom synthesis services: support kg-class custom synthesis, process optimization and impurity research, and provide exclusive technical support for innovative drug projects.
5.
Exporting experience: long-term stable supply of domestic and foreign pharmaceutical enterprises, CRO/CDMO companies and research institutes, with perfect export qualification and compliance document support (SDS, DMF format data, etc.).
Welcome to visit our official website for details: https://www.shlzpharma.com/
Post time: Oct-14-2026
