| Name | 7-Troc-paclitaxel;7-(2,2,2-Trichloroethyloxycarbonyl)taxol |
| Alias | 7-Troc-Paclitaxel;7-(2,2,2-Trichloroethyloxycarbonyl)taxol;Paclitaxel Impurity 50;Intermediate of paclitaxel;Paclitaxel N-1 Intermediate;(N-1)Paxlitaxl intermediate 2;7-Troc-paclitaxel, 98%min;7-{[(2,2,2,-Trichloroethyl)oxy]carbonyl} Paclitaxel |
| CAS No. | 114915-17-2 |
| chemical formula | C50H52Cl3NO16 |
| molecular weight | 1029.31 (about 1029.3g/mol) |
| InChI | InChI=1S/C50H52Cl3NO16/c1-26-32(67-44(61)37(57)36(29-16-10-7-11-17-29)54-42(59)30-18-12-8-13-19-30)23-49(63)41(69-43(60)31-20-14-9-15-21-31)39-47(6,40(58)38(66-27(2)55)35(26)46(49,4)5)33(68-45(62)65-25-50(51,52)53)22-34-48(39,24-64-34)70-28(3)56/h7-21,32-34,36-39,41,57,63H,22-25H2,1-6H3,(H,54,59)/t32-,33-,34+,36-,37+,38+,39-,41-,47+,48-,49+/m0/s1 |
| InChIKey | ARZHVJDHKCYODM-MUQZGBOESA-N |
| density | 1.46±0.1 g/cm3(Predicted) |
| boiling Point | 1041.1±65.0 °C(Predicted) |
| water soluble | no clear water solubility data; public information suggests that it is soluble in chloroform and ethyl acetate, and soluble/preparable in DMSO; it should be determined according to experiments. |
| Storage conditions | shading, drying and sealing; short-term 0-4 ℃ or 2-8 ℃, long-term recommendation -20 ℃ to avoid moisture storage; label/SDS shall prevail |
| sensitivity | it is recommended to manage as light, heat, and moisture-sensitive advanced taxane intermediates; specific sensitivity is subject to stability studies |
| appearance | solid Powder/Crystalline Powder |
| specific Gravity | about 1.46 (of the same magnitude as the predicted density; predicted value) |
| color | off-white/white to off-white |
| safety terminology | there is no S phrases for this CAS. Refer to SDS to avoid inhalation of dust, contact with eyes/skin, and keep away from oxidants and strong acids and alkalis. |
| Customs Number | china HS reference: 382290 (other organic compounds, subject to pre-classification/customs declaration); US HTS reference: 2934.99.03.00 |
nature
7-(2,2, 2-trichloroethyloxycarbonyl) paclitaxel is a taxane derivative in which the 7-position hydroxyl group of paclitaxel is protected by a Troc protecting group, and belongs to N-1 key intermediate/protected intermediate in the semi-synthetic route of paclitaxel. Its molecular formula is C50H52Cl3NO16, its molecular weight is about 1029.31, and its appearance is mostly white to almost white solid powder. The predicted density is about 1.46g/cm3 and the predicted boiling point is about 1041.1°C, which is suitable for low temperature, light-proof and sealing management according to high value-added and low-dose intermediates.
Use
it is mainly used for the semi-synthesis research of taxane antitumor drugs such as paclitaxel/docetaxel, and can be used as a key intermediate for the coupling of 10-deacetylbacardine III with C13 side chain, selective functional group transformation and deprotection precursor. It can also be used for paclitaxel impurity research, analysis method development, quality control and scientific research reagent scenarios. Publicly available information shows that its use includes the reaction of taxol with docetaxel semisynthetic and antitumor active molecules.
Safety Information
this product is intended for industrial/scientific use and should not be used for human or animal clinical diagnosis or treatment. Wear lab coat, goggles, nitrile gloves and dust mask during operation to avoid dust inhalation and eye/skin contact. Weighing and transfer should be carried out in the fume hood. Wastes shall be classified and collected according to halogen-containing organic waste liquid/solid waste, and shall not be directly discharged into sewers. If used for registration declaration, your SDS, elemental impurity/residual solvent/genotoxic impurity assessment and stability data shall prevail.
Our company’s production advantages and capacity (it is recommended to unify the external caliber; please replace the occupied space according to the actual situation)
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process advantages: experience in low-temperature protection, selective acylation/deprotection and crystallization purification of taxane intermediates, with high purity, low impurity profile and batch consistency.
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quality advantages: COA support can be provided for HPLC purity, related substances, chiral/optical purity, moisture, residual solvents, heavy metals/elemental impurities and microbial items; key impurities can be customized.
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delivery advantages: support g-kg -100kg flexible supply, research and development batch, verification batch and commercial batch can be connected; Can provide aluminum foil bags/brown bottles/paper barrels and other light-proof packaging.
Compliance Statement: ISO/GMP-like management documents, change control, deviation/OOS handling and traceability system can be provided; if registration is involved, DMF/CEP or customer audit data preparation is supported, but it is not recommended to fabricate certification before obtaining it.
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welcome to visit our official website for more products, specifications and customized services: https://www.shlzpharma.com/
Post time: Oct-26-2026
