High-Purity 4-Bromo-3-fluoro-2-methylaniline (CAS 127408-03-1)

4-Bromo-3-fluoro-2-methylaniline is a halogen-substituted aromatic amine with the molecular formula C7H7BrFN and a molecular weight of approximately 204.04 g/mol.

Product Name:Diphenyl-2-pyridylphosphine

CAS NO.:37943-90-1

Synonyms:

2-Pyridyldiphenylphosphine;

Diphenyl(2-pyridinyl)phosphine;

2-(diphenylphosphanyl)pyridine;

2-Diphenylphosphinopyridine,min.97%;

DPPPY/DIPHENYL-2-PYRIDYL;Diphenyl-2-pyridylphosphine97%;

DIPHENYL-2-PYRIDYLPHOSPHINE;

2-(DIPHENYLPHOSPHINO)PYRIDINE

Its molecular structure includes four key functional components:

• · Bromine (Br): enhances electrophilic substitution and cross-coupling reactivity
• · Fluorine (F): improves metabolic stability, lipophilicity, and bioavailability in drug design
• · Aromatic amine (-NH2): provides a flexible reactive site for further derivatization
• · Methyl group (-CH3): modulates steric hindrance and electronic density

This combination gives the molecule strong versatility in multi-step organic synthesis, making it suitable for constructing complex pharmaceutical intermediates and high-value fine chemicals.

Under standard conditions, the compound is typically a white to off-white crystalline solid, stable under controlled temperature and dry storage environments.

In the rapidly evolving global pharmaceutical and fine chemical industry, the demand for high-quality halogenated aromatic intermediates continues to increase significantly. Among these key compounds, 4-Bromo-3-fluoro-2-methylaniline (CAS No. 127408-03-1) has emerged as an essential building block in modern organic synthesis, particularly in pharmaceutical research, agrochemical development, and advanced functional material science.

With the continuous expansion of precision medicine and structure-based drug design, pharmaceutical companies require intermediates that offer high purity, stable supply chains, and reliable batch consistency. These requirements directly influence research efficiency, cost control, and final API quality.

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. is a professional manufacturer and global supplier of fine chemicals and pharmaceutical intermediates. The company is dedicated to providing high-performance chemical building blocks that support innovation in drug discovery and industrial synthesis.

Applications in Pharmaceutical and Chemical Industry

1.Pharmaceutical Intermediate Synthesis

One of the most significant applications of CAS 127408-03-1 is its role as a core pharmaceutical intermediate. It is widely used in the synthesis of:

• · Kinase inhibitors
• · Anti-cancer drug candidates
• · Central nervous system (CNS) active compounds
• · Advanced API (Active Pharmaceutical Ingredient) structures

In modern drug discovery, fluorinated and brominated aromatic compounds are highly valued because they allow medicinal chemists to optimize:

• · Binding affinity to biological targets
• · Metabolic stability
• · Selectivity and pharmacokinetic properties

This makes 4-Bromo-3-fluoro-2-methylaniline an important scaffold in structure-activity relationship (SAR) optimization.

2.Cross-Coupling Reaction Chemistry

This compound is particularly suitable for modern organic transformations, including:

• · Suzuki-Miyaura coupling reactions
• · Buchwald-Hartwig amination
• · Carbon–carbon and carbon–nitrogen bond formation

These reactions are widely used in:

• · Pharmaceutical synthesis
• · Heterocyclic compound construction
• · OLED and organic electronic material development
• · Functional dye chemistry

Its dual halogen substitution provides selective reactivity control, making it an efficient intermediate for complex molecular architectures.

3.Agrochemical and Material Science Applications

Beyond pharmaceutical use, 4-Bromo-3-fluoro-2-methylaniline also plays an important role in:

• · Herbicide and pesticide intermediate production
• · Advanced dye and pigment chemistry
• · Functional polymer materials
• · Organic electronic and semiconductor materials

The presence of halogen atoms improves chemical durability and allows for fine tuning of physicochemical properties in industrial formulations.

 Quality Assurance by Shanghai Lizhuo Pharmaceutical Technology Co., Ltd.

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. is a professional supplier focusing on high-purity pharmaceutical intermediates and fine chemical production. The company integrates R&D, manufacturing, and global distribution capabilities.

1 High Purity Standards

The company ensures that CAS 127408-03-1 meets strict quality requirements:

• · Low impurity profile suitable for advanced synthesis
• · Excellent batch-to-batch reproducibility

These standards ensure consistent performance in sensitive chemical reactions.

2 Advanced Analytical Quality Control System

Each production batch is tested using internationally recognized analytical methods:

• · HPLC (High Performance Liquid Chromatography) for purity analysis
• · GC (Gas Chromatography) for volatile impurity detection
• · NMR spectroscopy for structural confirmation
• · Comprehensive COA (Certificate of Analysis) provided for each shipment

This ensures full traceability and compliance with global research standards.

3 Scalable Production Capability

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. supports flexible production models:

• · Gram-scale for laboratory research
• · Kilogram-scale for pilot projects
• · Industrial bulk supply for commercial manufacturing

This scalability allows the company to serve both early-stage R&D institutions and large pharmaceutical manufacturers.

4 Global Supply Chain and Service Network

The company provides stable supply to customers across:

• · Europe
• · North America
• · Asia-Pacific regions

Key advantages include:

• · Fast international logistics
• · Customized packaging solutions
• · Technical support for synthesis applications
• · Stable long-term supply agreements

 Market Trends and SEO Industry Insights

From a global SEO and pharmaceutical industry perspective, CAS 127408-03-1 belongs to a high-commercial-intent keyword cluster.

Future Development Outlook

With the advancement of precision medicine and sustainable chemistry, demand for halogenated aromatic intermediates is expected to continue growing.

Key future trends include:

• · Expansion of fluorinated drug molecules in oncology and CNS therapies
• · Green chemistry and environmentally friendly synthesis routes
• · AI-assisted molecular design in drug discovery
• · Increasing regulatory requirements for high-purity intermediates (≥97%)

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. is actively investing in R&D innovation and process optimization to meet these evolving global demands.

 Conclusion

4-Bromo-3-fluoro-2-methylaniline (CAS 127408-03-1) is a critical intermediate in modern pharmaceutical and fine chemical synthesis. Its unique structural properties enable wide applications in drug discovery, agrochemicals, and advanced material science.

With strong manufacturing capabilities, strict quality control systems, and global supply chain integration, Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. continues to strengthen its position as a trusted international supplier.

As the pharmaceutical industry moves toward more complex and precise molecular design, this compound will remain an essential building block for next-generation therapeutic innovation and industrial chemical development.