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Name	Methyl-d3-amine hydrochloride / Methylamine-d3 hydrochloride
Alias	Methan-d3-amine hydrochloride;Methyl-d3-amine monohydrochloride;Methyl-d3-ammonium chloride;Monomethyl-d3-ammonium chloride;trideuteriomethanamine hydrochloride;Deuterated methylamine hydrochloride;METHYL-D3-AMINE HYDROCHLORIDE, 99 ATOM % D
CAS No.	7436-22-8
EINECS No.	231-089-6
chemical formula	structural formula: CD3NH2 · HCl; Common library writing method CH2D3N.ClH / CH3D3ClN / CH6ClN (isotope labeling caliber is different, essentially the same)
molecular weight	70.54 (about 70.5365, slightly different by isotopic composition)
InChI	InChI=1S/CH5N.ClH/c1-2;/h2H2,1H3;1H/i1D3;
water soluble	soluble in DMSO and methanol; Slightly soluble/slightly soluble in water; The specific solubility is subject to the measured COA
storage conditions	cool, dry, sealed preservation; moisture-proof, dark, away from strong oxidants and acid mist; sensitive to moisture
sensitivity	hygroscopicity/hygroscopicity risk; attention should also be paid to batch isotope abundance and moisture control for deuterated products
appearance	solid; white to off-white
color	white to almost white
MDL No.	MFCD00064559
dangerous Goods Signs	xi: Irritant substance
risk Terms	R36/37/38 Irritating to eyes, respiratory system and skin
safety terminology	S26-S36 (skin contact/eye wash and consult a doctor; wear appropriate protective clothing; avoid inhalation of dust)
customs Number	there is no unified public HS; deuterated/stable isotope classification caliber is easy to change due to different uses and purity, it is recommended to import and export pre-classification or customs declaration opinions shall prevail.

Nature

deuterated methylamine hydrochloride is the hydrochloride form of methylamine methyl trideuterated, which has the dual properties of “easy storage/easy weighing of hydrochloride” and “deuterated methyl building block. At room temperature for white to white solid, melting point of about 232-234 ° C; soluble in DMSO, methanol, slightly soluble in water. As a C1 deuterated amine source, the core value lies in the introduction of CD3N fragments with high isotope abundance, which provides stable, controllable and scalable starting materials for NMR, metabolic tracing, reaction mechanism research and deuterated drug synthesis. Disclosure of physical properties in the density, boiling point, flash point, vapor pressure, refractive index and other missing data, commercial/technical documents should be based on our COA, MSDS and measured methods.

Use

it is mainly used for the synthesis of deuterated drugs and pharmaceutical intermediates, especially the fragments that need to be introduced into deuterated methylamine/deuterated methylamino structure; It is suitable for the intermediate route of deuterated drugs such as deuterated lexitinib, stable isotope labeled impurity reference substance, NMR quantitative/qualitative research, drug metabolism and pharmacokinetic tracing, and nucleophilic amination/methylation block in organic synthesis. Typical value points include: improving metabolic stability, reducing the risk of deuterated site exchange, supporting impurity spectrum research and isotope internal standard development, and serving gram-level research and development, kilogram-level pilot to commercial supply.

Safety Information

treat as irritant solid: avoid inhaling dust, avoid contact with eyes, skin and clothing; wear protective glasses, gloves and dust mask during operation, and keep local ventilation. In case of contact with eyes or skin, rinse immediately with plenty of water and seek medical advice. Separate from the strong oxidant and strong acid system; isolate the contaminated area in case of leakage, and put it into a closed container for disposal as chemical waste after collection. Transport and storage shall follow the principles of moisture-proof, sealing, cool and dry; classification, labeling and disposal shall be subject to the latest SDS and local regulations.

Our production advantages and capacity

autonomous and controllable deuterated synthesis and purification platform, covering small-scale test, kilogram-scale pilot test and commercial amplification, supporting customized deuterated degree, purity, moisture, inorganic salt and residual solvent indicators.

Batch stability: release standards can be established around deuteration abundance (e.g. 98%/99%/99.8 atom % D), HPLC purity, related substances and isotope exchange stability, and COA, MSDS, HNMR/LCMS and other data can be provided.

Quality and Compliance: Implement strict change control, sample retention and traceability management for pharmaceutical intermediate scenarios, and support the supplement of impurity mass and stability data required for registration/declaration data.

supply flexibility: conventional can provide gram-kg spot and fast delivery, and can be scaled up to 10kg, 100kg or even ton according to project demand.

service advantages: support packaging specification customization, sub-packaging, cold chain/moisture-proof packaging, third-party testing and global regulatory data matching, suitable for research and development, process transfer and commercialization stage.