N-phenylbis (trifluoromethanesulfonimide) | CAS 37595-74-7

N-phenylbis (trifluoromethanesulfonimide) | CAS 37595-74-7 | High purity PhNTf₂ reagent supplier | Annual production capacity 20 tons

specializing in the supply of N-phenyl bis (trifluoromethanesulfonimide) CAS 37595-74-7, purity ≥ 99%, annual production capacity of 20 tons. As a highly efficient trifluoromethanesulfonylation reagent, it is widely used in the synthesis of pharmaceutical intermediates, materials science and asymmetric catalysis. Get COA/MSDS and free samples.

H1: N-Phenylbis (trifluoromethanesulfonimide) CAS 37595-74-7: High Performance Trifluoromethanesulfonylation Solution

n-phenylbis (trifluoromethanesulfonimide) (PhNTf₂ for short, CAS No. 37595-74-7) is an indispensable core reagent in the field of organic synthesis and pharmaceutical research and development. As a mild and efficient trifluoromethanesulfonylation reagent (Triflating Reagent), it is replacing the traditional harsh reaction conditions and helping laboratories and pharmaceutical companies to achieve safer and more selective chemical transformations.

If you are looking for a reliable 37595-74-7 supplier, or need high purity N-phenyl bis trifluoromethanesulfonimide for scale-up production, this article will help you fully understand the core value and procurement points of this product.

H2: Why is PhNTf₂ the preferred trifluoromethanesulfonylation reagent for modern organic synthesis?

In transition metal-catalyzed cross-coupling reactions (such as Suzuki, Heck, Stille couplings), aryl triflates (Ar-OTf) are the key synthetic building blocks. Although the traditional trifluoromethanesulfonic anhydride (Tf₂ O) has high activity, the reaction conditions are severe, the side reactions are many, and the operation is dangerous.

The advantages of N-phenylbis (trifluoromethanesulfonimide) are:

mild reaction conditions: no extreme low temperature or strong acid environment, can achieve the efficient esterification of phenols, amines trifluoromethanesulfonic acid

excellent selectivity: the ditrifluoromethanesulfonyl structure gives it strong electrophilicity while maintaining non-nucleophilicity, reducing the generation of by-products

high operational safety: solid form is easy to weigh and feed, and is more suitable for industrial amplification than liquid Tf₂ O.

Wide compatibility: Excellent synergistic effect with various catalytic systems (palladium catalysis, nickel catalysis, photocatalysis)

H2: Core Application Areas: From Laboratory Research to Industrial Production

H3: Pharmaceutical R & D and Active Molecule Synthesis

in the research and development of innovative drugs, 37595-74-7 is a powerful weapon for building complex molecular skeletons:

enantioselective Synthesis of β-Amino Acids: Introducing Chiral Centers through Mannich Reactions to Provide Key Intermediates for Antibiotics and Peptide Drugs

kinase inhibitor development: molecular construction for LRRK2 inhibitors, antibacterial drugs and other targets

sphingosine-1-phosphate receptor (S1P1) agonists: an important role in autoimmune disease drug development

H3: Advanced Materials and Electronic Chemicals

beyond traditional organic synthesis, N-phenyl bis-trifluoromethanesulfonimide shows unique value in materials science:

carbon nanotubes p-type doping: as a transparent strong electron-withdrawing dopant, significantly improve the conductivity and stability of carbon nanotubes, applied to flexible electronic devices.

Battery electrolyte additives: Optimize the electrochemical performance of graphite electrodes in lithium-ion and dual-ion batteries to extend cycle life

ion-selective membrane development: providing the basis for chemical modification of separation membranes and functional polymer materials

H3: Asymmetric Catalysis and Total Synthesis of Natural Products

for green synthesis in pursuit of atom economy, PhNTf₂ supports:

stereoselective sulfoxide reaction

precise preparation of α-boryl aldehyde amphoteric compounds

enantioselective construction of the core ring skeleton of natural products (such as leucosceptroids A- D)

H2: Product Specification and Quality Commitment

the N-phenyl bis (trifluoromethanesulfonimide) 37595-74-7 we supply strictly implements the pharmaceutical grade internal control standard:

H2: Why choose us as your long-term partner?

Independent R & D and process stability

we use trifluoromethanesulfonyl fluoride gas method (low temperature -40°C ~ 0°C, negative pressure-0.095MPa), with completely independent intellectual property rights. Compared with the traditional route, the process has higher selectivity, less three wastes, and the inter-batch stability RSD is less than 0.3%.

Capacity and Supply Chain Assurance

annual production capacity of 20 tons, conventional inventory of 2-5 tons, support from gram-level reagents to ton-level industrial raw materials flexible procurement

1-3 working days for spot orders, 7-15 working days for custom orders

upstream raw materials (trifluoromethanesulfonyl fluoride, aniline) direct supply channels, price competitiveness, no fear of market fluctuations

compliance and Global Exports

certified to ISO 9001 and ISO 14001

in line with the requirements of REACH regulations, the products have been exported to Europe, America, Japan, South Korea and Southeast Asian markets.

Provide complete export documents: COA, MSDS, TDS, dangerous goods transportation identification report

technical support and customized services

fluorine chemistry expert team provides synthesis route consultation and optimization suggestions for scale-up process

support special purity (99.8), special particle size (≤ 0.02 μm) and special packaging (nitrogen-filled aluminum foil bag/barrel) customization

H2: Guidelines for Safe Operation and Storage

n-Phenylbis (trifluoromethanesulfonimide) is an irritant chemical (Dangerous Goods Mark: Xi). Protective gloves, goggles and dust mask must be worn during operation to ensure good ventilation. The product is sensitive to moisture, and it is recommended to use it immediately after opening or keep it sealed with nitrogen. In case of skin contact, wash immediately with plenty of soapy water; in case of eye contact, rinse with running water for 15 minutes and seek medical attention.

H2: Frequently Asked Questions (FAQ)

H3: What is the difference between N-phenylbis (trifluoromethanesulfonimide) and trifluoromethanesulfonic anhydride (Tf₂ O)?

PhNTf₂ is a solid reagent, which is safer to operate and more selective. It is suitable for reactions that are sensitive to moisture or require mild conditions. Tf₂ O is more active but dangerous, and it is not easy to accurately feed liquids. In most aryl triflation reactions, PhNTf₂ is the preferred industrial choice.

H3: What is the minimum order quantity for 37595-74-7?

We support flexible MOQ: reagent grade minimum order 1 gram, industrial grade minimum order 1kg. For small test needs in the research and development stage, we provide fast sample service.

H3: Is the product suitable for API synthesis under GMP conditions?

Yes. We can provide batches that meet the standards of pharmaceutical intermediates, and issue corresponding quality documents and stability data according to customer requirements. For GMP level products, please contact our technical team for audit and customization.

H3: How to judge whether the received product has deteriorated?

The normal product is a white to off-white crystalline powder. If clumping, discoloration, or deliquescence is evident, this may be due to exposure to moisture. It is recommended to always store it in the original packaging with nitrogen and use it as soon as possible after opening.

H2: Get quotes and free samples now

whether you are conducting laboratory tests, pilot scale-up or commercial production, we can provide you with a stable and reliable supply plan for N-phenyl bis (trifluoromethanesulfonimide) CAS 37595-74-7.