Strategic Analysis of 5-bromo-4-fluoro-1H-indazole in Pharmaceutical Synthesis

Chemical Profile

Structure and Formula

You will find that 5-bromo-4-fluoro-1H-indazole has a unique chemical structure. This structure gives it special properties that make it useful in drug development. The compound contains both bromine and fluorine atoms attached to an indazole ring. These atoms help create new molecules for medicines. Here is a table that shows the main chemical details:

The high purity means you can trust the results when you use this compound in your research. The molecular formula and weight help you plan your experiments and calculate the right amounts.

Physical and Chemical Properties

You will notice that 5-bromo-4-fluoro-1H-indazole appears as a light pink powder. This makes it easy to handle and measure. The compound has a boiling point of about 332.2°C, which shows it can stay stable at high temperatures. This property is important when you need to heat the compound during synthesis. The density is close to 1.7 g/cm³, so you can predict how it will behave in different solutions.

These properties help you understand how the compound will react in the lab. You can use this information to choose the right conditions for your experiments.

Storage and Stability

You should store 5-bromo-4-fluoro-1H-indazole in a dark place at room temperature. Keep the container sealed to protect it from air and moisture. This will help the compound stay pure and effective for a long time. The high boiling point also means it will not evaporate easily, so you can use it safely in many types of chemical reactions.

Tip: Always check the storage instructions before you start your work. Proper storage keeps your chemicals safe and ready for use.

The stability and storage needs of this compound make it a reliable choice for pharmaceutical synthesis. You can count on its quality and performance in your research.

Intermediate for Orforglipron and Pharmaceutical Synthesis

Role in Orforglipron Synthesis

You play a key role in drug discovery when you use 5-bromo-4-fluoro-1H-indazole as an intermediate for Orforglipron and pharmaceutical synthesis. This compound helps you build the main structure of Orforglipron, a medicine that targets the GLP-1 receptor. You start with 1,4-dibromo-2-fluorobenzene. You use a process called lithiation to change its structure. Then, you react it with dimethyl formamide. This step gives you 3,6-dibromo-2-fluorobenzaldehyde. You mix this with methyl hydrazine to make a hydrazone. The hydrazone forms a ring in a reaction called Ullmann ring closure. This final step gives you 5-bromo-4-fluoro-1-methyl-1H-indazole. You get a yield of about 53.7%. This pathway shows how important 5-bromo-4-fluoro-1H-indazole is as an intermediate for Orforglipron and pharmaceutical synthesis.

Note: Each step in this process lets you control the final product. You can make sure the medicine works the way you want.

You will find that 5-bromo-4-fluoro-1H-indazole stands out in pharmaceutical synthesis because of its high purity and unique chemical structure. As an intermediate for Orforglipron and pharmaceutical synthesis, this compound supports the creation of complex drugs. The table below shows why researchers and industry professionals value it:

You should understand its advantages, challenges, and future opportunities to make the most of this valuable compound.

Shanghai Lizhuo Pharmaceutical Technology Co., Ltd. is not only a supplier of this product but also your technical partner in research and development. From cutting-edge technology development to in-depth technical consultation, they provide professional support throughout the entire product lifecycle.

Key Takeaways

• · 5-bromo-4-fluoro-1H-indazole is a key intermediate in drug synthesis, particularly for Orforglipron, making it essential for developing new medicines.
• · The compound boasts a high purity of 98%, ensuring reliable results and consistent outcomes in pharmaceutical research and production.
• · Proper storage in a dark, sealed container at room temperature is crucial to maintain the compound’s effectiveness and stability.
• · This compound allows for the creation of diverse drug molecules, making it valuable in research for diseases like cancer and diabetes.
• · Safety is paramount; always wear protective gear and work in a well-ventilated area when handling this compound.

Applications in Drug Development

You can use 5-bromo-4-fluoro-1H-indazole in many drug development projects. This compound acts as a building block for new medicines. You can add different groups to the indazole ring. This lets you create many types of drugs. You find this compound in research for cancer, diabetes, and other diseases. As an intermediate for Orforglipron and pharmaceutical synthesis, it helps you make complex molecules that are hard to build in other ways. You can trust its high purity and stable structure. This means your results will be reliable.

You see that this compound opens doors to many new treatments. You can explore new ideas in your lab with confidence.

Use in Fused Triazine Derivatives

You also use 5-bromo-4-fluoro-1H-indazole to make fused triazine derivatives. These molecules have a special ring structure. You find them in many modern medicines. The compound helps you build 1,2,4-triazine-3-amine derivatives. These are important in both research and industry. You can change the structure to fit your needs. This flexibility makes it a top choice as an intermediate for Orforglipron and pharmaceutical synthesis.

• · You start with the indazole compound.
• · You add other chemicals to form the triazine ring.
• · You get new molecules with special properties.

You can use these new molecules to test for new drugs. You can also use them in other chemical industries. This shows how valuable 5-bromo-4-fluoro-1H-indazole is for your work.

Tip: When you use this compound, you save time and resources. You can focus on testing and discovery instead of long synthesis steps.

Strategic Roles in Synthesis

Building Block in Medicinal Chemistry

You can use 5-bromo-4-fluoro-1H-indazole as a strong building block in medicinal chemistry. This compound helps you create many new drug molecules. You find it at the center of many important reactions. Scientists use it to make halogenated indazole derivatives. These derivatives are important for organic synthesis and drug research. You can also use this compound as an intermediate for Orforglipron and pharmaceutical synthesis. It supports the design of medicines that fight diseases like cancer and inflammation.

Tip: When you start with a reliable building block, you can explore more ideas in your lab.

Functionalization Potential

You can change 5-bromo-4-fluoro-1H-indazole in many ways. The bromine and fluorine atoms on the ring make it easy to add new groups. You can use cross-coupling reactions to attach other molecules. This lets you build 4-fluoro-5-substituted indazole derivatives. These new compounds can become fine chemicals or materials for new technology. You can also use this compound to make targeted drug molecules, such as SHP2 inhibitors and EP3 receptor antagonists. These drugs help treat lung cancer and diabetes.

• · You can add different groups to the indazole ring.
• · You can create new molecules for testing.
• · You can discover new treatments for major diseases.

Value in Research and Industry

You will see the value of 5-bromo-4-fluoro-1H-indazole in both research and industry. Many universities and research institutes use this compound as a high-quality reagent. It helps you design new drug molecules and test their activity. In pharmaceutical R&D labs, you use it as a basic raw material. It supports the early stages of drug development and helps you move from an idea to a real medicine.

• · You can use it for drug molecular design.
• · You can screen for new drug activity.
• · You can support innovative drug projects.

This compound gives you a strong foundation for your work. You can trust its quality and flexibility in many fields.

Advantages in Drug Development

High Purity and Quality Control

You benefit from the high purity of 5-bromo-4-fluoro-1H-indazole. The compound reaches a purity level of 98%. This means you can trust your results in every experiment. You avoid unwanted side reactions. You get consistent outcomes in your synthesis. Quality control becomes easier for you. You can rely on the compound for both small-scale research and large-scale production.

Tip: Always check the purity label before you start your project. High purity saves you time and resources.

Here is a quick summary of the benefits:

Enabling Novel Scaffolds

You use 5-bromo-4-fluoro-1H-indazole to create new molecular scaffolds. The unique structure lets you build complex molecules. You can design new drugs for many diseases. The indazole ring gives you flexibility. You can attach different groups to the ring. This helps you explore new chemical spaces.

• · You can make new cancer drugs.
• · You can develop diabetes treatments.
• · You can test new compounds for material science.

You expand your research possibilities with this compound. You discover new pathways for drug development.

Selectivity and Reactivity

You gain selectivity and reactivity when you use this compound. The bromine and fluorine atoms make the indazole ring reactive. You can perform targeted reactions. You can add new groups with precision. This helps you make molecules with special functions.

Note: Selectivity means you get the product you want. Reactivity lets you try new reactions in your lab.

You control the synthesis process. You achieve high yields. You create molecules that meet your needs. The compound supports your innovation in pharmaceutical research.

Challenges and Considerations

Synthetic Limitations

You may face some challenges when you use 5-bromo-4-fluoro-1H-indazole in synthesis. The compound has a unique structure, so you need to select the right reaction conditions. Sometimes, you must use special catalysts or reagents to achieve the desired transformation. You may find that the bromine and fluorine atoms limit the types of reactions you can perform. You need to plan your synthesis steps carefully to avoid unwanted byproducts.

Tip: Always test your reaction conditions with small amounts before scaling up. This helps you save time and resources.

Here is a quick summary of common synthetic considerations:

Safety and Handling

You must handle 5-bromo-4-fluoro-1H-indazole with care. The compound is a fine powder, so you should avoid inhaling it. You need to wear gloves and goggles to protect your skin and eyes. You should work in a well-ventilated area or use a fume hood. You must keep the container sealed to prevent moisture and contamination.

• · Wear protective equipment at all times.
• · Store the compound in a dark, dry place.
• · Dispose of waste according to local guidelines.

Note: Safety first! Always read the safety data sheet before you start your work.

Regulatory Aspects

You need to follow regulations when you use 5-bromo-4-fluoro-1H-indazole in your research or production. You must check if your country has rules for handling, storing, or transporting this compound. You may need to keep records of how you use and dispose of it. You should follow environmental guidelines to prevent pollution.

You ensure compliance by staying informed and following best practices. This protects you, your team, and the environment.

Case Studies

Approved Pharmaceuticals

You can see how 5-bromo-4-fluoro-1H-indazole plays a role in real medicines. Drug makers use this compound to build important parts of new drugs. You find it in the development of kinase inhibitors. These drugs target proteins like GSK-3, ROCK, JAK, and Aurora. They help treat diseases by blocking harmful signals in the body. You also see this compound in pain management. Pfizer uses it in their patent for Nav1.7 inhibitors. The clinical candidate PF-05241328 shows strong activity with an IC₅₀ of 31 nM. You find it in patents for ENL/AF9 YEATS inhibitors, which help fight leukemia.

• · You use 5-bromo-4-fluoro-3-methyl-1H-indazole to make kinase inhibitors for cancer and inflammation.
• · You find it in pain medicines, such as Nav1.7 inhibitors.
• · You see it in leukemia treatments, helping doctors fight cancer.

Tip: When you study approved drugs, you learn how this compound supports real-world therapies.

Recent Research Examples

You discover that researchers use 5-bromo-4-fluoro-1H-indazole in many new projects. Scientists test it as a starting point for making fused triazine derivatives. These molecules show promise in treating diabetes and cancer. You see it in studies that explore new ways to block disease pathways. Researchers use it to build molecules with special shapes and functions. You find it in academic papers and patents that focus on drug discovery.

• · You see it in experiments for diabetes drugs.
• · You find it in cancer research projects.
• · You notice it in studies about new chemical reactions.

Industrial Applications

You notice that industry professionals rely on 5-bromo-4-fluoro-1H-indazole for large-scale production. Chemical companies use it to make advanced materials and pharmaceutical intermediates. You see it in quality control labs, where experts test its purity and stability. Manufacturers use it to create batches of drug candidates for clinical trials. You find it in supply chains that support research and development.

Note: You help drive innovation in industry when you use this compound for new products and processes.

Future Perspectives

Trends in Indazole Chemistry

You will see many new trends in indazole chemistry. Scientists focus on making indazole scaffolds in new ways. These methods help you create molecules with better properties for medicine. Indazole compounds show many biological activities, so researchers pay close attention to them. You can find these trends in the field:

• · New ways to build indazole rings make synthesis faster and easier.
• · Researchers study the biological effects of indazole compounds for new treatments.
• · Many teams work on improving the pharmacological properties of indazole derivatives.
• · You will notice more interest in indazole scaffolds because they can help treat many diseases.
• · Innovative methods help you make indazole compounds that are important for drug discovery.

Note: Indazole chemistry keeps growing because these molecules can help fight many health problems.

Potential for New Therapeutics

You can use 5-bromo-4-fluoro-1H-indazole to create new medicines. This compound acts as a key building block for halogenated indazole derivatives. Its unique structure makes it valuable in drug research and development. You can modify the indazole core to design molecules with different biological activities. This helps you target diseases like cancer, neurological disorders, and diabetes. For example, you can make SHP2 inhibitors, EP3 receptor antagonists, or TRPV1 receptor blockers. You also use this compound to prepare 4-fluoro-5-substituted indazole derivatives. These are important in both fine chemicals and new materials.

• · You support drug design and activity screening.
• · You help with studies that link structure to function in new drugs.
• · You open new paths for treating major diseases.

Ongoing Research

You will find that research on indazole compounds continues to expand. Scientists look for new ways to use 5-bromo-4-fluoro-1H-indazole in drug discovery. Many labs test new reactions and study how changes in the molecule affect its activity. You can join these efforts by exploring new modifications and testing their effects. This ongoing research helps you find better treatments and understand how indazole compounds work.

Tip: Stay updated with the latest studies. You can discover new uses for indazole compounds and help shape the future of medicine.

You see that 5-bromo-4-fluoro-1H-indazole stands out as a valuable intermediate for Orforglipron and other pharmaceuticals. Its high purity and unique indazole core help you create new medicines. You benefit from its reliable reactivity and easy handling.

• · Many researchers report smooth reactions and fewer troubleshooting steps.
• · Reliable supply chains and safety practices support your work.
• · The compound’s structure lets you design novel therapies and drive drug discovery.

You can expect this compound to keep shaping the future of pharmaceutical synthesis.5-bromo-4-fluoro-1H-indazole CAS NO.1082041-85-7is our regularly production product, whether you need small sample or a large cargo of more than tonnage, our company Shanghai Lizhuo Pharmaceutical Technology Co., Ltd.can supply it formally