Taxol side chain (N-benzoyl-(2R,3S)-3-phenylisoserine)
| Name | N-Benzoyl-(2R,3S)-3-phenylisoserine |
| Alias | Taxol side chain; TAXOL(R) SIDE CHAIN; Paclitaxel Impurity 30; Paclitaxel Impurity N1; Paclitaxel Side Chain Impurity 1; (2R,3S)-N-Benzoyl-3-phenyl Isoserine; (2R,3S)-3-Benzamido-2-hydroxy-3-phenylpropanoic acid |
| CAS No. | 132201-33-3 |
| EINECS No. | 631-348-7 |
| chemical formula | C₁₆H₁₅NO₄ |
| molecular weight | 285.29(285.3) |
| InChI | InChI=1S/C16H15NO4/c18-14(16(20)21)13(11-7-3-1-4-8-11)17-15(19)12-9-5-2-6-10-12/h1-10,13-14,18H,(H,17,19)(H,20,21)/t13-,14+/m0/s1 |
| density | 1.316±0.06g/cm³ (predicted) |
| boiling Point | 580.7±50.0°C at 760 mmHg (predicted) |
| flash Point | 305°C |
| water soluble | slightly soluble in water; soluble in methanol, ethanol, DMSO, acetonitrile and other organic solvents |
| vapor pressure | 2.51×10⁻¹⁴ mmHg at 25°C |
| refractive index | 1.625 |
| storage conditions | sealed, dry and stored at room temperature (refrigerated at 2-8°C recommended, long-term storage -20°C recommended) |
| sensitivity | sensitive to moisture and light |
| appearance | solid powder |
| specific Gravity | 1.316 (predicted) |
| color | white to almost white |
| melting Point | 169-172°C (lit.) |
| specific optical rotation | [α]²⁰/D −40°(c = 1.0 in ethanol) |
| MDL No. | MFCD00274633 |
| dangerous Goods Signs | xi-Irritant Items |
| risk Terms | r36/37/38-Irritating to eyes, respiratory system and skin |
| safety terminology | s26-Immediately after contact with eyes, rinse with plenty of water and seek medical advice; S36-Wear appropriate protective clothing |
| customs Number | 29242990 |
nature of 1. (Properties)
n-benzoyl-(2R,3S)-3-phenylisoserine is a chiral side chain at the C- 13 position of paclitaxel. The molecule contains two chiral centers (2R,3S configuration), which is essential for the strong anti-tumor activity of paclitaxel. The product is white to off-white crystalline powder with a melting point of 169-172°C, with clear optical rotation, stable chemical properties, and stable storage under recommended storage conditions.
2. Use (Applications)
this product is the key chiral intermediate of semi-synthetic paclitaxel (Paclitaxel) and docetaxel (Docetaxel). It is the core raw material to solve the scarcity of natural sources of paclitaxel and realize industrial semi-synthesis by condensation with Baccatin Ⅲ (paclitaxel Ⅲ). At the same time, it is widely used in paclitaxel impurity control, paclitaxel side chain synthesis process research, paclitaxel hybrid and antimalarial drug candidate design and other scientific research fields.
3. Safety Information (Safety Information)
GHS Classification: Skin Irritation Category 2, Severe Eye Irritation Category 2, Specific Target Organ Toxicity (One Exposure) Category 3. Use should wear protective gloves and goggles, avoid inhalation of dust, only in a well-ventilated place to operate; such as contact with eyes, immediately rinse with a large amount of water and medical treatment; this product does not belong to the category of dangerous goods transport, can be transported by common chemicals by land, sea and air.
Our production advantages and capacity
purity advantage: using asymmetric synthesis process, product purity ≥ 99.0 (HPLC), chiral purity (ee/de)≥ 99.5, impurity profile controllable, in line with the requirements of API intermediate declaration;
quality assurance: each batch provides HPLC, NMR, MS, specific rotation of a full set of COA and MSDS, through the ISO 9001 quality management system certification, can accept customer audit;
capacity guarantee: it has a dedicated multi-functional production workshop, with an annual output of XX tons of paclitaxel side chain (which can be filled in according to the actual situation), and a 100kg spot supply, which can stably meet the commercial procurement demand;
cost and delivery: direct supply from the source factory, no intermediate links, obvious price advantage; regular orders are shipped within 3-5 working days, and custom packaging specifications are supported;
technical service: equipped with senior synthetic technical team, can provide technical support and impurity research service of paclitaxel semi-synthetic process.
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welcome to visit our official website for more product details and cooperation information: https://www.shlzpharma.com/
Post time: Oct-26-2026
